2p2h: Difference between revisions

Revision as of 22:45, 25 July 2012

2p2h is a 1 chain structure of Vascular Endothelial Growth Factor Receptor with sequence from Homo sapiens. Full crystallographic information is available from OCA.

↑ Hodous BL, Geuns-Meyer SD, Hughes PE, Albrecht BK, Bellon S, Bready J, Caenepeel S, Cee VJ, Chaffee SC, Coxon A, Emery M, Fretland J, Gallant P, Gu Y, Hoffman D, Johnson RE, Kendall R, Kim JL, Long AM, Morrison M, Olivieri PR, Patel VF, Polverino A, Rose P, Tempest P, Wang L, Whittington DA, Zhao H. Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor. J Med Chem. 2007 Feb 22;50(4):611-26. Epub 2007 Jan 25. PMID:17253678 doi:10.1021/jm061107l

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 [[Image:2p2h.png|left|200px]]
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 ===Crystal structure of the VEGFR2 kinase domain in complex with a pyridinyl-triazine inhibitor===
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