2jgv: Difference between revisions
New page: left|200px<br /> <applet load="2jgv" size="450" color="white" frame="true" align="right" spinBox="true" caption="2jgv, resolution 2.00Å" /> '''STRUCTURE OF STAPHY... |
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==About this Structure== | ==About this Structure== | ||
2JGV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]] with ADP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.144 2.7.1.144]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JGV OCA]]. | 2JGV is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]] with ADP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Tagatose-6-phosphate_kinase Tagatose-6-phosphate kinase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.144 2.7.1.144]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2JGV OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Staphylococcus aureus]] | [[Category: Staphylococcus aureus]] | ||
[[Category: Tagatose-6-phosphate kinase]] | |||
[[Category: Hunter, W.N.]] | [[Category: Hunter, W.N.]] | ||
[[Category: Leonard, G.A.]] | [[Category: Leonard, G.A.]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
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Revision as of 14:36, 30 October 2007
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STRUCTURE OF STAPHYLOCOCCUS AUREUS D-TAGATOSE-6-PHOSPHATE KINASE IN COMPLEX WITH ADP
OverviewOverview
High resolution structures of Staphylococcus aureus d-tagatose-6-phosphate, kinase (LacC) in two crystal forms are herein reported. The structures, define LacC in apoform, in binary complexes with ADP or the co-factor, analogue AMP-PNP, and in a ternary complex with AMP-PNP and, D-tagatose-6-phosphate. The tertiary structure of the LacC monomer, which, is closely related to other members of the pfkB subfamily of carbohydrate, kinases, is composed of a large alpha/beta core domain and a smaller, largely beta "lid." Four extended polypeptide segments connect these two, domains. Dimerization of LacC occurs via interactions between lid domains, which come together to form a beta-clasp structure. Residues from both, subunits contribute to substrate binding. LacC adopts a closed structure, ... [(full description)]
About this StructureAbout this Structure
2JGV is a [Single protein] structure of sequence from [Staphylococcus aureus] with ADP as [ligand]. Active as [Tagatose-6-phosphate kinase], with EC number [2.7.1.144]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structures of Staphylococcus aureus D-tagatose-6-phosphate kinase implicate domain motions in specificity and mechanism., Miallau L, Hunter WN, McSweeney SM, Leonard GA, J Biol Chem. 2007 Jul 6;282(27):19948-57. Epub 2007 Apr 25. PMID:17459874
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