1bmp: Difference between revisions
New page: left|200px<br /> <applet load="1bmp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bmp, resolution 2.8Å" /> '''BONE MORPHOGENETIC P... |
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[[Image:1bmp.gif|left|200px]]<br /> | [[Image:1bmp.gif|left|200px]]<br /><applet load="1bmp" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1bmp" size=" | |||
caption="1bmp, resolution 2.8Å" /> | caption="1bmp, resolution 2.8Å" /> | ||
'''BONE MORPHOGENETIC PROTEIN-7'''<br /> | '''BONE MORPHOGENETIC PROTEIN-7'''<br /> | ||
==Overview== | ==Overview== | ||
We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a | We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a member of the transforming growth factor beta (TGF-beta) superfamily of proteins and is able to induce new bone formation in vivo. Members of this superfamily share sequence similarity in their C-terminal regions and are implicated in embryonic development and adult tissue repair. Our crystal structure makes possible the structural comparison between two members of the TGF-beta superfamily. We find that although there is limited sequence identity between OP-1 and TGF-beta 2, they share a common polypeptide fold. These results establish a basis for proposing the OP-1/TGF-beta 2 fold as the primary structural motif for the TGF-beta superfamily as a whole. Detailed comparison of the OP-1 and TGF-beta 2 structures has revealed striking differences that provide insights into how these growth factors interact with their receptors. | ||
==About this Structure== | ==About this Structure== | ||
1BMP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1BMP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BMP OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Griffith, D | [[Category: Griffith, D L.]] | ||
[[Category: Scott, D | [[Category: Scott, D L.]] | ||
[[Category: bone]] | [[Category: bone]] | ||
[[Category: cartilage]] | [[Category: cartilage]] | ||
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[[Category: transforming growth factor]] | [[Category: transforming growth factor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:56:52 2008'' | ||
Revision as of 12:56, 21 February 2008
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BONE MORPHOGENETIC PROTEIN-7
OverviewOverview
We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a member of the transforming growth factor beta (TGF-beta) superfamily of proteins and is able to induce new bone formation in vivo. Members of this superfamily share sequence similarity in their C-terminal regions and are implicated in embryonic development and adult tissue repair. Our crystal structure makes possible the structural comparison between two members of the TGF-beta superfamily. We find that although there is limited sequence identity between OP-1 and TGF-beta 2, they share a common polypeptide fold. These results establish a basis for proposing the OP-1/TGF-beta 2 fold as the primary structural motif for the TGF-beta superfamily as a whole. Detailed comparison of the OP-1 and TGF-beta 2 structures has revealed striking differences that provide insights into how these growth factors interact with their receptors.
About this StructureAbout this Structure
1BMP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Three-dimensional structure of recombinant human osteogenic protein 1: structural paradigm for the transforming growth factor beta superfamily., Griffith DL, Keck PC, Sampath TK, Rueger DC, Carlson WD, Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):878-83. PMID:8570652
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