1biw: Difference between revisions
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==Overview== | ==Overview== | ||
A novel series of conformationally constrained matrix metalloprotease | A novel series of conformationally constrained matrix metalloprotease inhibitors was identified. The potencies observed for these inhibitors were highly dependent upon the substitution pattern on the caprolactam ring as well as the succinate moiety. | ||
==Disease== | ==Disease== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Stromelysin 1]] | [[Category: Stromelysin 1]] | ||
[[Category: Almstead, N | [[Category: Almstead, N G.]] | ||
[[Category: Anastasio, M | [[Category: Anastasio, M B.]] | ||
[[Category: Barnett, B | [[Category: Barnett, B L.]] | ||
[[Category: Bradley, R | [[Category: Bradley, R S.]] | ||
[[Category: Cheng, M.]] | [[Category: Cheng, M.]] | ||
[[Category: De, B.]] | [[Category: De, B.]] | ||
[[Category: Dunaway, C | [[Category: Dunaway, C M.]] | ||
[[Category: McIver, J | [[Category: McIver, J M.]] | ||
[[Category: McPhail, S | [[Category: McPhail, S J.]] | ||
[[Category: Mieling, G | [[Category: Mieling, G E.]] | ||
[[Category: Natchus, M | [[Category: Natchus, M G.]] | ||
[[Category: Pikul, S.]] | [[Category: Pikul, S.]] | ||
[[Category: Snider, C | [[Category: Snider, C E.]] | ||
[[Category: Taiwo, Y | [[Category: Taiwo, Y O.]] | ||
[[Category: Wahl, C | [[Category: Wahl, C T.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
[[Category: S80]] | [[Category: S80]] | ||
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[[Category: structure-based drug design]] | [[Category: structure-based drug design]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:55:46 2008'' | ||
Revision as of 12:55, 21 February 2008
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DESIGN AND SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED MMP INHIBITORS
OverviewOverview
A novel series of conformationally constrained matrix metalloprotease inhibitors was identified. The potencies observed for these inhibitors were highly dependent upon the substitution pattern on the caprolactam ring as well as the succinate moiety.
DiseaseDisease
Known diseases associated with this structure: Coronary heart disease, susceptibility to OMIM:[185250]
About this StructureAbout this Structure
1BIW is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Stromelysin 1, with EC number 3.4.24.17 Full crystallographic information is available from OCA.
ReferenceReference
Design and synthesis of conformationally-constrained MMP inhibitors., Natchus MG, Cheng M, Wahl CT, Pikul S, Almstead NG, Bradley RS, Taiwo YO, Mieling GE, Dunaway CM, Snider CE, McIver JM, Barnett BL, McPhail SJ, Anastasio MB, De B, Bioorg Med Chem Lett. 1998 Aug 18;8(16):2077-80. PMID:9873489
Page seeded by OCA on Thu Feb 21 11:55:46 2008
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Homo sapiens
- Single protein
- Stromelysin 1
- Almstead, N G.
- Anastasio, M B.
- Barnett, B L.
- Bradley, R S.
- Cheng, M.
- De, B.
- Dunaway, C M.
- McIver, J M.
- McPhail, S J.
- Mieling, G E.
- Natchus, M G.
- Pikul, S.
- Snider, C E.
- Taiwo, Y O.
- Wahl, C T.
- CA
- S80
- ZN
- Matrix metalloprotease
- Osteoarthritis
- Protein crystal structure
- Stromelysin
- Structure-based drug design