1bau: Difference between revisions

Revision as of 12:53, 21 February 2008

NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE

OverviewOverview

Retroviral genomes must dimerize to be fully infectious. Dimerization is directed by a unique RNA hairpin structure with a palindrome in its loop: hairpins of two strands first associate transiently through their loops, and then refold to a more stable, linear duplex. The structure of the initial, kissing-loop dimer from HIV-1, solved using 2D NMR, is bent and metastable, its interface being formed not only by standard basepairing between palindromes, but also by a distinctive pattern of interstrand stacking among bases at the stem-loop junctions. This creates mechanical distortions that partially melt both stems, which may facilitate spontaneous refolding of this RNA complex into linear form.

About this StructureAbout this Structure

1BAU is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

ReferenceReference

Structure of the dimer initiation complex of HIV-1 genomic RNA., Mujeeb A, Clever JL, Billeci TM, James TL, Parslow TG, Nat Struct Biol. 1998 Jun;5(6):432-6. PMID:9628479

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 '''NMR STRUCTURE OF THE DIMER INITIATION COMPLEX OF HIV-1 GENOMIC RNA, MINIMIZED AVERAGE STRUCTURE'''<br />
 ==Overview==
-Retroviral genomes must dimerize to be fully infectious. Dimerization is, directed by a unique RNA hairpin structure with a palindrome in its loop:, hairpins of two strands first associate transiently through their loops, and then refold to a more stable, linear duplex. The structure of the, initial, kissing-loop dimer from HIV-1, solved using 2D NMR, is bent and, metastable, its interface being formed not only by standard basepairing, between palindromes, but also by a distinctive pattern of interstrand, stacking among bases at the stem-loop junctions. This creates mechanical, distortions that partially melt both stems, which may facilitate, spontaneous refolding of this RNA complex into linear form.
+Retroviral genomes must dimerize to be fully infectious. Dimerization is directed by a unique RNA hairpin structure with a palindrome in its loop: hairpins of two strands first associate transiently through their loops, and then refold to a more stable, linear duplex. The structure of the initial, kissing-loop dimer from HIV-1, solved using 2D NMR, is bent and metastable, its interface being formed not only by standard basepairing between palindromes, but also by a distinctive pattern of interstrand stacking among bases at the stem-loop junctions. This creates mechanical distortions that partially melt both stems, which may facilitate spontaneous refolding of this RNA complex into linear form.
 ==About this Structure==
-BAU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BAU OCA].
+BAU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAU OCA].
 ==Reference==
 Structure of the dimer initiation complex of HIV-1 genomic RNA., Mujeeb A, Clever JL, Billeci TM, James TL, Parslow TG, Nat Struct Biol. 1998 Jun;5(6):432-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9628479 9628479]
 [[Category: Protein complex]]
-[[Category: Billeci, T.M.]]
+[[Category: Billeci, T M.]]
-[[Category: Clever, J.L.]]
+[[Category: Clever, J L.]]
-[[Category: James, T.L.]]
+[[Category: James, T L.]]
 [[Category: Mujeeb, A.]]
-[[Category: Parslow, T.G.]]
+[[Category: Parslow, T G.]]
 [[Category: dimerization]]
 [[Category: encapsidation]]
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 [[Category: rna]]
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