1b9w: Difference between revisions

Revision as of 12:53, 21 February 2008

C-TERMINAL MEROZOITE SURFACE PROTEIN 1 FROM PLASMODIUM CYNOMOLGI

OverviewOverview

The C-terminal proteolytic processing product of merozoite surface protein 1 (MSP1) appears essential for successful erythrocyte invasion by the malarial parasite, Plasmodium. We have determined the crystal structure at 1.8 A resolution of a soluble baculovirus-recombinant form of the protein from P. cynomolgi, which confers excellent protective efficacy in primate vaccination trials. The structure comprises two EGF-like domains, and sequence comparisons strongly suggest that the same conformation is present in all species of Plasmodium, including P. falciparum and P. vivax, which are pathogenic in man. In particular, conserved interdomain contacts between the two EGF modules should preserve the compact form of the molecule in all species. Implications of the crystal structure for anti-malarial vaccine development are discussed.

About this StructureAbout this Structure

1B9W is a Single protein structure of sequence from Plasmodium cynomolgi. Full crystallographic information is available from OCA.

ReferenceReference

The crystal structure of C-terminal merozoite surface protein 1 at 1.8 A resolution, a highly protective malaria vaccine candidate., Chitarra V, Holm I, Bentley GA, Petres S, Longacre S, Mol Cell. 1999 Apr;3(4):457-64. PMID:10230398

Page seeded by OCA on Thu Feb 21 11:53:03 2008

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OCA

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-[[Image:1b9w.jpg|left|200px]]<br /><applet load="1b9w" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1b9w.jpg|left|200px]]<br /><applet load="1b9w" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1b9w, resolution 1.800&Aring;" />
 '''C-TERMINAL MEROZOITE SURFACE PROTEIN 1 FROM PLASMODIUM CYNOMOLGI'''<br />
 ==Overview==
-The C-terminal proteolytic processing product of merozoite surface protein, 1 (MSP1) appears essential for successful erythrocyte invasion by the, malarial parasite, Plasmodium. We have determined the crystal structure at, 1.8 A resolution of a soluble baculovirus-recombinant form of the protein, from P. cynomolgi, which confers excellent protective efficacy in primate, vaccination trials. The structure comprises two EGF-like domains, and, sequence comparisons strongly suggest that the same conformation is, present in all species of Plasmodium, including P. falciparum and P., vivax, which are pathogenic in man. In particular, conserved interdomain, contacts between the two EGF modules should preserve the compact form of, the molecule in all species. Implications of the crystal structure for, anti-malarial vaccine development are discussed.
+The C-terminal proteolytic processing product of merozoite surface protein 1 (MSP1) appears essential for successful erythrocyte invasion by the malarial parasite, Plasmodium. We have determined the crystal structure at 1.8 A resolution of a soluble baculovirus-recombinant form of the protein from P. cynomolgi, which confers excellent protective efficacy in primate vaccination trials. The structure comprises two EGF-like domains, and sequence comparisons strongly suggest that the same conformation is present in all species of Plasmodium, including P. falciparum and P. vivax, which are pathogenic in man. In particular, conserved interdomain contacts between the two EGF modules should preserve the compact form of the molecule in all species. Implications of the crystal structure for anti-malarial vaccine development are discussed.
 ==About this Structure==
-B9W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_cynomolgi Plasmodium cynomolgi]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1B9W OCA].
+B9W is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Plasmodium_cynomolgi Plasmodium cynomolgi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B9W OCA].
 ==Reference==
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 [[Category: Plasmodium cynomolgi]]
 [[Category: Single protein]]
-[[Category: Bentley, G.A.]]
+[[Category: Bentley, G A.]]
 [[Category: Chitarra, V.]]
 [[Category: Holm, I.]]
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 [[Category: surface antigen]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:55:28 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:53:03 2008''