Sandbox 122: Difference between revisions

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'''Kapβ2 Cargo Binding and Conformational Change4'''
'''Kapβ2 Cargo Binding and Conformational Change4'''


The NLSs located on Kapβ2 cargos are named the PY- NLS and they bind to the C-terminal arch of Kapβ2.
The <scene name='Sandbox_122/Kapb2_nls_blue_magenta/3'>NLSs</scene> located on Kapβ2 cargos are named the PY- NLS and they bind to the C-terminal arch of Kapβ2.


    
    
Recognition of the PY-NLS by Kapβ2 follows certain guidelines:
Recognition of the PY-NLS by Kapβ2 follows certain guidelines:


(i)  <scene name='Sandbox_122/Kapb2_nls_blue_magenta/3'>PY-NLS</scene>, when not bound to Kapβ2, lacks a secondary structure.
(i)  PY-NLS, when not bound to Kapβ2, lacks a secondary structure.


(ii) PY-NLS has an overall positive charge allowing for electrostatic compatibility with Kapβ2.
(ii) PY-NLS has an overall positive charge allowing for electrostatic compatibility with Kapβ2.

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Wayne Decatur, Student, Allison Granberry, Marisa L. VanBrakle