Sandbox 122: Difference between revisions
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'''Kapβ2 Cargo Binding and Conformational Change4''' | '''Kapβ2 Cargo Binding and Conformational Change4''' | ||
The NLSs located on Kapβ2 cargos are named the PY- NLS and they bind to the C-terminal arch of Kapβ2. | The <scene name='Sandbox_122/Kapb2_nls_blue_magenta/3'>NLSs</scene> located on Kapβ2 cargos are named the PY- NLS and they bind to the C-terminal arch of Kapβ2. | ||
Recognition of the PY-NLS by Kapβ2 follows certain guidelines: | Recognition of the PY-NLS by Kapβ2 follows certain guidelines: | ||
(i) | (i) PY-NLS, when not bound to Kapβ2, lacks a secondary structure. | ||
(ii) PY-NLS has an overall positive charge allowing for electrostatic compatibility with Kapβ2. | (ii) PY-NLS has an overall positive charge allowing for electrostatic compatibility with Kapβ2. |