1aol: Difference between revisions

Revision as of 12:46, 21 February 2008

FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN

OverviewOverview

An essential step in retrovirus infection is the binding of the virus to its receptor on a target cell. The structure of the receptor-binding domain of the envelope glycoprotein from Friend murine leukemia virus was determined to 2.0 angstrom resolution by x-ray crystallography. The core of the domain is an antiparallel beta sandwich, with two interstrand loops forming a helical subdomain atop the sandwich. The residues in the helical region, but not in the beta sandwich, are highly variable among mammalian C-type retroviruses with distinct tropisms, indicating that the helical subdomain determines the receptor specificity of the virus.

About this StructureAbout this Structure

1AOL is a Single protein structure of sequence from Friend murine leukemia virus with and as ligands. Full crystallographic information is available from OCA.

ReferenceReference

Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution., Fass D, Davey RA, Hamson CA, Kim PS, Cunningham JM, Berger JM, Science. 1997 Sep 12;277(5332):1662-6. PMID:9287219

Page seeded by OCA on Thu Feb 21 11:46:41 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1aol.gif|left|200px]]<br /><applet load="1aol" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1aol.gif|left|200px]]<br /><applet load="1aol" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1aol, resolution 2.0&Aring;" />
 '''FRIEND MURINE LEUKEMIA VIRUS RECEPTOR-BINDING DOMAIN'''<br />
 ==Overview==
-An essential step in retrovirus infection is the binding of the virus to, its receptor on a target cell. The structure of the receptor-binding, domain of the envelope glycoprotein from Friend murine leukemia virus was, determined to 2.0 angstrom resolution by x-ray crystallography. The core, of the domain is an antiparallel beta sandwich, with two interstrand loops, forming a helical subdomain atop the sandwich. The residues in the helical, region, but not in the beta sandwich, are highly variable among mammalian, C-type retroviruses with distinct tropisms, indicating that the helical, subdomain determines the receptor specificity of the virus.
+An essential step in retrovirus infection is the binding of the virus to its receptor on a target cell. The structure of the receptor-binding domain of the envelope glycoprotein from Friend murine leukemia virus was determined to 2.0 angstrom resolution by x-ray crystallography. The core of the domain is an antiparallel beta sandwich, with two interstrand loops forming a helical subdomain atop the sandwich. The residues in the helical region, but not in the beta sandwich, are highly variable among mammalian C-type retroviruses with distinct tropisms, indicating that the helical subdomain determines the receptor specificity of the virus.
 ==About this Structure==
-AOL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Friend_murine_leukemia_virus Friend murine leukemia virus] with NAG and ZN as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AOL OCA].
+AOL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Friend_murine_leukemia_virus Friend murine leukemia virus] with <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AOL OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Friend murine leukemia virus]]
 [[Category: Single protein]]
-[[Category: Berger, J.M.]]
+[[Category: Berger, J M.]]
-[[Category: Cunningham, J.M.]]
+[[Category: Cunningham, J M.]]
-[[Category: Davey, R.A.]]
+[[Category: Davey, R A.]]
 [[Category: Fass, D.]]
-[[Category: Hamson, C.A.]]
+[[Category: Hamson, C A.]]
-[[Category: Kim, P.S.]]
+[[Category: Kim, P S.]]
 [[Category: NAG]]
 [[Category: ZN]]
@@ Line 25: / Line 25: @@
 [[Category: viral glycoprotein]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 11:00:20 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:46:41 2008''