1ajv: Difference between revisions
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==Overview== | ==Overview== | ||
Two cyclic, C2-symmetric HIV-1 protease inhibitors, one sulfamide and one | Two cyclic, C2-symmetric HIV-1 protease inhibitors, one sulfamide and one urea derivative, both comprising phenyl ether groups in the P1/P1' positions, were cocrystallized with HIV-1 protease, and the crystal structures were determined to 2.0 A resolution. The structure of the urea 2 showed a conformation similar to that reported for the related urea 3 by Lam et al., while the sulfamide 1 adopted an unanticipated conformation in which the P1' and P2' side chains were transposed. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: protease]] | [[Category: protease]] | ||
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Revision as of 12:45, 21 February 2008
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HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC SULFAMIDE INHIBITOR AHA006
OverviewOverview
Two cyclic, C2-symmetric HIV-1 protease inhibitors, one sulfamide and one urea derivative, both comprising phenyl ether groups in the P1/P1' positions, were cocrystallized with HIV-1 protease, and the crystal structures were determined to 2.0 A resolution. The structure of the urea 2 showed a conformation similar to that reported for the related urea 3 by Lam et al., while the sulfamide 1 adopted an unanticipated conformation in which the P1' and P2' side chains were transposed.
About this StructureAbout this Structure
1AJV is a Single protein structure of sequence from Human immunodeficiency virus type 1 (isolate 12) with as ligand. Active as HIV-1 retropepsin, with EC number 3.4.23.16 Full crystallographic information is available from OCA.
ReferenceReference
Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor., Backbro K, Lowgren S, Osterlund K, Atepo J, Unge T, Hulten J, Bonham NM, Schaal W, Karlen A, Hallberg A, J Med Chem. 1997 Mar 14;40(6):898-902. PMID:9083478
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