3bhu: Difference between revisions
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Revision as of 12:34, 25 July 2012
Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 5Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 5
Template:ABSTRACT PUBMED 17804748
About this StructureAbout this Structure
3bhu is a 4 chain structure of Cell Division Protein Kinase 2 and Cyclin with sequence from Bos taurus and Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Bettayeb K, Tirado OM, Marionneau-Lambot S, Ferandin Y, Lozach O, Morris JC, Mateo-Lozano S, Drueckes P, Schachtele C, Kubbutat MH, Liger F, Marquet B, Joseph B, Echalier A, Endicott JA, Notario V, Meijer L. Meriolins, a new class of cell death inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases. Cancer Res. 2007 Sep 1;67(17):8325-34. PMID:17804748 doi:67/17/8325
- ↑ Echalier A, Bettayeb K, Ferandin Y, Lozach O, Clement M, Valette A, Liger F, Marquet B, Morris JC, Endicott JA, Joseph B, Meijer L. Meriolins (3-(pyrimidin-4-yl)-7-azaindoles): synthesis, kinase inhibitory activity, cellular effects, and structure of a CDK2/cyclin A/meriolin complex. J Med Chem. 2008 Feb 28;51(4):737-51. Epub 2008 Jan 31. PMID:18232649 doi:10.1021/jm700940h
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Pages with broken file links
- Bos taurus
- Cyclin-dependent kinase
- Homo sapiens
- Bettayeb, K.
- Clement, M.
- Echalier, A.
- Endicott, J A.
- Ferandin, Y.
- Joseph, B.
- Liger, F.
- Lozach, O.
- Marquet, B.
- Meijer, L.
- Morris, J C.
- Valette, A.
- Atp-binding
- Cell cycle
- Cell division
- Cyclin
- Mitosis
- Nucleotide-binding
- Phosphoprotein
- Phosphorylation
- Ser/thr protein kinase
- Serine/threonine-protein kinase
- Transferase