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[[Image:3ik3.png|left|200px]]
[[Image:3ik3.png|left|200px]]


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===AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance===
===AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance===


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==About this Structure==
==About this Structure==
3IK3 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK3 OCA].  
[[3ik3]] is a 2 chain structure of [[Proto-oncogene tyrosine-protein kinase]] with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IK3 OCA].  
 
==See Also==
*[[Proto-oncogene tyrosine-protein kinase|Proto-oncogene tyrosine-protein kinase]]


==Reference==
==Reference==
<ref group="xtra">PMID:19878872</ref><references group="xtra"/>
<ref group="xtra">PMID:019878872</ref><references group="xtra"/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Non-specific protein-tyrosine kinase]]
[[Category: Zhou, T.]]
[[Category: Zhou, T.]]
[[Category: Alternative splicing]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Bcr-abl]]
[[Category: Bcr-abl]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]
[[Category: Chromosomal rearrangement]]
[[Category: Cml]]
[[Category: Cml]]
[[Category: Cytoplasm]]
[[Category: Cytoskeleton]]
[[Category: Cytoskeleton]]
[[Category: Drug resistance]]
[[Category: Drug resistance]]
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[[Category: T315i]]
[[Category: T315i]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 10:53:11 2010''

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