1w0h: Difference between revisions
New page: left|200px<br /> <applet load="1w0h" size="450" color="white" frame="true" align="right" spinBox="true" caption="1w0h, resolution 1.59Å" /> '''CRYSTALLOGRAPHIC ST... |
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==About this Structure== | ==About this Structure== | ||
1W0H is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MG and AMP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W0H OCA]]. | 1W0H is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with MG and AMP as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: MGA. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1W0H OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: nuclease domain]] | [[Category: nuclease domain]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:31:38 2007'' | ||
Revision as of 14:26, 30 October 2007
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CRYSTALLOGRAPHIC STRUCTURE OF THE NUCLEASE DOMAIN OF 3'HEXO, A DEDDH FAMILY MEMBER, BOUND TO RAMP
OverviewOverview
A human 3'-5'-exoribonuclease (3'hExo) has recently been identified and, shown to be responsible for histone mRNA degradation. Functionally, 3'hExo, and a stem-loop binding protein (SLBP) target opposite faces of a unique, highly conserved stem-loop RNA scaffold towards the 3' end of histone, mRNA, which is composed of a 6 bp stem and a 4 nt loop, followed by an, ACCCA sequence. Its Caenorhabditis elegans homologue, ERI-1, has been, shown to degrade small interfering RNA in vitro and to function as a, negative regulator of RNA interference in neuronal cells. We have, determined the structure of the nuclease domain (Nuc) of 3'hExo complexed, with rAMP in the presence of Mg2+ at 1.6 A resolution. The Nuc domain, adopts an alpha/beta globular fold, with four acidic residues coordinating, a ... [(full description)]
About this StructureAbout this Structure
1W0H is a [Single protein] structure of sequence from [Homo sapiens] with MG and AMP as [ligands]. Structure known Active Site: MGA. Full crystallographic information is available from [OCA].
ReferenceReference
Crystallographic structure of the nuclease domain of 3'hExo, a DEDDh family member, bound to rAMP., Cheng Y, Patel DJ, J Mol Biol. 2004 Oct 15;343(2):305-12. PMID:15451662
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