P53-DNA Recognition: Difference between revisions

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===Protein-Protein Interactions===
===Protein-Protein Interactions===


The human p53 tetramer forms a relatively small <scene name='Sandbox_Reserved_170/Intra-dimer/4'>intra-dimer interface with two salt bridges between Glu180 and Arg181 residues</scene> and, in comparison, a large <scene name='Sandbox_Reserved_170/Inter-dimer/4'>inter-dimer interface with an extensive network of interactions</scene>. The actual molecular interactions and strength in binding can vary as functions of the sequence and spacer length of the response element.
The human p53 tetramer forms a relatively small <scene oldname='Sandbox_Reserved_170/Intra-dimer/4' name='P53-DNA_Recognition/P53_intra-dimer/1'>intra-dimer interface with two salt bridges between Glu180 and Arg181 residues</scene> and, in comparison, a large <scene name='Sandbox_Reserved_170/Inter-dimer/4'>inter-dimer interface with an extensive network of interactions</scene>. The actual molecular interactions and strength in binding can vary as functions of the sequence and spacer length of the response element.


===Major Groove Base Readout===
===Major Groove Base Readout===