Hox protein: Difference between revisions
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==Recognition of Scr Specific vs. Hox Consensus Site== | ==Recognition of Scr Specific vs. Hox Consensus Site== | ||
<Structure load='2r5y' size='300' frame='true' align='right' caption='Figure 5: 3D-Representation of Exd-Scr-DNA ternary complex with Hox consensus site; [http://proteopedia.com/wiki/index.php/2r5y PDB ID# 2R5Y].' scene='Sandbox_Reserved_169/Con/3' /> | <Structure load='2r5y' size='300' frame='true' align='right' caption='Figure 5: 3D-Representation of <font color="blue">'''Exd'''</font>-<span style="background-color: black; color: yellow;">''' Scr '''</span>-DNA ternary complex with Hox consensus site; [http://proteopedia.com/wiki/index.php/2r5y PDB ID# 2R5Y].' scene='Sandbox_Reserved_169/Con/3' /> | ||
This observation can be explained based on a second crystal structure of an Scr-Exd-DNA ternary complex where the Hox-Exd hetrodimer is bound to a Hox consensus site, which is not specific to Scr (<scene name='Sandbox_Reserved_169/Con/3'>restore initial scene</scene>). In this structure it is apparent that only <scene name='Sandbox_Reserved_169/Con/2'>Arg5 binds the minor groove</scene> and the remainder of the N-terminal linker is disordered (Figure 5).<br/> | This observation can be explained based on a second crystal structure of an Scr-Exd-DNA ternary complex where the Hox-Exd hetrodimer is bound to a Hox consensus site, which is not specific to Scr (<scene name='Sandbox_Reserved_169/Con/3'>restore initial scene</scene>). In this structure it is apparent that only <scene name='Sandbox_Reserved_169/Con/2'>Arg5 binds the minor groove</scene> and the remainder of the N-terminal linker is disordered (Figure 5).<br/> | ||