Hox protein: Difference between revisions
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Both <span style="background-color: black; color: yellow;">''' Scr '''</span> and <font color="blue">'''Exd'''</font> belong to the family of homeodomain proteins, which are encoded by homeoboxes. Homeodomains are helix-turn-helix motifs (<scene name='Sandbox_Reserved_169/Complex/1'>restore initial scene</scene>) comprised of three alpha helices (Figure 3). The DNA-binding interface residues of both proteins are <scene name='Sandbox_Reserved_169/Complex/2'> evolutionarily most conserved</scene>. {{Template:ColorKey_ConSurf_NoYellow_NoGray}} | Both <span style="background-color: black; color: yellow;">''' Scr '''</span> and <font color="blue">'''Exd'''</font> belong to the family of homeodomain proteins, which are encoded by homeoboxes. Homeodomains are helix-turn-helix motifs (<scene name='Sandbox_Reserved_169/Complex/1'>restore initial scene</scene>) comprised of three alpha helices (Figure 3). The DNA-binding interface residues of both proteins are <scene name='Sandbox_Reserved_169/Complex/2'> evolutionarily most conserved</scene>. {{Template:ColorKey_ConSurf_NoYellow_NoGray}} | ||
The third alpha helix of the Scr and Exd homeodomains, the so-called <scene name='Sandbox_Reserved_169/Scr_recognition_helix/3'>recognition helix</scene>, inserts into the major groove where hydrogen bonds are formed between protein side chains and base pairs. An N-terminal tail forms contacts with the minor groove.<br/> | The third alpha helix of the <span style="background-color: black; color: yellow;">''' Scr '''</span> and <font color="blue">'''Exd'''</font> homeodomains, the so-called <scene name='Sandbox_Reserved_169/Scr_recognition_helix/3'>recognition helix</scene>, inserts into the major groove where hydrogen bonds are formed between protein side chains and base pairs. An N-terminal tail forms contacts with the minor groove.<br/> | ||
===Hox Protein-Cofactor Interactions=== | ===Hox Protein-Cofactor Interactions=== | ||