1a0a: Difference between revisions

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OCA

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-[[Image:1a0a.gif|left|200px]]<br /><applet load="1a0a" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1a0a.gif|left|200px]]<br /><applet load="1a0a" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1a0a, resolution 2.800&Aring;" />
 '''PHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO4/DNA COMPLEX'''<br />
 ==Overview==
-The crystal structure of a DNA-binding domain of PHO4 complexed with DNA, at 2.8 A resolution revealed that the domain folds into a, basic-helix-loop-helix (bHLH) motif with a long but compact loop that, contains a short alpha-helical segment. This helical structure positions a, tryptophan residue into an aromatic cluster so as to make the loop, compact. PHO4 binds to DNA as a homodimer with direct reading of both the, core E-box sequence CACGTG and its 3'-flanking bases. The 3'-flanking, bases GG are recognized by Arg2 and His5. The residues involved in the, E-box recognition are His5, Glu9 and Arg13, as already reported for, bHLH/Zip proteins MAX and USF, and are different from those recognized by, bHLH proteins MyoD and E47, although PHO4 is a bHLH protein.
+The crystal structure of a DNA-binding domain of PHO4 complexed with DNA at 2.8 A resolution revealed that the domain folds into a basic-helix-loop-helix (bHLH) motif with a long but compact loop that contains a short alpha-helical segment. This helical structure positions a tryptophan residue into an aromatic cluster so as to make the loop compact. PHO4 binds to DNA as a homodimer with direct reading of both the core E-box sequence CACGTG and its 3'-flanking bases. The 3'-flanking bases GG are recognized by Arg2 and His5. The residues involved in the E-box recognition are His5, Glu9 and Arg13, as already reported for bHLH/Zip proteins MAX and USF, and are different from those recognized by bHLH proteins MyoD and E47, although PHO4 is a bHLH protein.
 ==About this Structure==
-A0A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A0A OCA].
+A0A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A0A OCA].
 ==Reference==
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 [[Category: transcription factor]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 10:31:47 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:39:29 2008''