190d: Difference between revisions

Revision as of 12:39, 21 February 2008

CRYSTAL STRUCTURE OF A FOUR-STRANDED INTERCALATED DNA: D(C4)

OverviewOverview

The crystal structure of d(C4) solved at 2.3-A resolution reveals a four-stranded molecule composed of two interdigitated or intercalated duplexes. The duplexes are held together by hemiprotonated cytosine-cytosine base pairs and are parallel stranded, but the two duplexes point in opposite directions. The molecule has a slow right-handed twist of 12.4 degrees between covalently linked cytosine base pairs, and the base stacking distance is 3.1 A. This is in general agreement with the NMR studies. A biological role for DNA in this conformation is suggested.

About this StructureAbout this Structure

190D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of a four-stranded intercalated DNA: d(C4)., Chen L, Cai L, Zhang X, Rich A, Biochemistry. 1994 Nov 22;33(46):13540-6. PMID:7947764

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 '''CRYSTAL STRUCTURE OF A FOUR-STRANDED INTERCALATED DNA: D(C4)'''<br />
 ==Overview==
-The crystal structure of d(C4) solved at 2.3-A resolution reveals a, four-stranded molecule composed of two interdigitated or intercalated, duplexes. The duplexes are held together by hemiprotonated, cytosine-cytosine base pairs and are parallel stranded, but the two, duplexes point in opposite directions. The molecule has a slow, right-handed twist of 12.4 degrees between covalently linked cytosine base, pairs, and the base stacking distance is 3.1 A. This is in general, agreement with the NMR studies. A biological role for DNA in this, conformation is suggested.
+The crystal structure of d(C4) solved at 2.3-A resolution reveals a four-stranded molecule composed of two interdigitated or intercalated duplexes. The duplexes are held together by hemiprotonated cytosine-cytosine base pairs and are parallel stranded, but the two duplexes point in opposite directions. The molecule has a slow right-handed twist of 12.4 degrees between covalently linked cytosine base pairs, and the base stacking distance is 3.1 A. This is in general agreement with the NMR studies. A biological role for DNA in this conformation is suggested.
 ==About this Structure==
-D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=190D OCA].
+D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=190D OCA].
 ==Reference==
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 [[Category: u-dna]]
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