Estrogen-related receptor: Difference between revisions
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Michal Harel (talk | contribs) No edit summary |
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{{STRUCTURE_2pgu| PDB=2pgu | SIZE=400| SCENE= |right|CAPTION=Human estrogen-related receptor γ complex with 4-hydroxytamoxifen, [[2pgu]] }} | {{STRUCTURE_2pgu| PDB=2pgu | SIZE=400| SCENE= |right|CAPTION=Human estrogen-related receptor γ complex with 4-hydroxytamoxifen, [[2pgu]] }} | ||
'''Estrogen-related receptor''' (ERR) binds to estrogen response elements on DNA and modulates transcription. ERR plays a role in energy homeostasis and cancer. There are 3 classes of ERR : ERRα, ERRβ and ERRγ. | '''Estrogen-related receptor''' (ERR) binds to estrogen response elements on DNA and modulates transcription. ERR plays a role in energy homeostasis and cancer. There are 3 classes of ERR : ERRα, ERRβ and ERRγ. | ||
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===ERRα=== | ===ERRα=== | ||
[[1xb7]], [[3d24 – hERR ligand-binding domain + peroxisome proliferator activated receptor coactivator 1 peptide – human<br />[[2pjl]] - hERR ligand-binding domain (mutant) + inverse agonist<br /> | [[1xb7]], [[3d24]] – hERR ligand-binding domain + peroxisome proliferator activated receptor coactivator 1 peptide – human<br />[[2pjl]] - hERR ligand-binding domain (mutant) + inverse agonist<br /> | ||
[[3k6p]] - hERR ligand-binding domain + ligand | [[3k6p]] - hERR ligand-binding domain + ligand | ||