Hox protein: Difference between revisions
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==Introduction and Biological Role of Hox Proteins== | ==Introduction and Biological Role of Hox Proteins== | ||
[[Image:Hox-intro.jpg|thumb|left| | [[Image:Hox-intro.jpg|thumb|left|250px|Figure 1: Crystal structure of Exd-Scr-DNA ternary complex; [http://www.rcsb.org/pdb/explore/explore.do?structureId=2r5z PDB ID# 2R5Z]<ref name="joshi">Joshi R, Passner JM, Rohs R, Jain R, Sosinsky A, Crickmore MA, Jacob V, Aggarwal AK, Honig B, Mann RS. Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell. 2007;131(3):530-43.</ref>. The Hox protein Scr (yellow) and its cofactor Exd (blue) bind to its specific ''fkh20'' site.]] | ||
[[Image:Cell.jpg|thumb|right|300px|Figure 2: Hox proteins require a cofactor to achieve high binding specificity in order to execute their distinct functions in developing various parts of the fly embryo <ref name="slattery">Slattery M, Riley T, Liu P, Abe N, Gomez-Alcala P, Dror I, Zhou T, Rohs R, Honig B, Bussemaker HJ, Mann RS. Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins. Cell. 2011;147(6):1270-82.</ref>. Elsevier/Cell Press has provided permission for usage of this figure.]] | [[Image:Cell.jpg|thumb|right|300px|Figure 2: Hox proteins require a cofactor to achieve high binding specificity in order to execute their distinct functions in developing various parts of the fly embryo <ref name="slattery">Slattery M, Riley T, Liu P, Abe N, Gomez-Alcala P, Dror I, Zhou T, Rohs R, Honig B, Bussemaker HJ, Mann RS. Cofactor binding evokes latent differences in DNA binding specificity between Hox proteins. Cell. 2011;147(6):1270-82.</ref>. Elsevier/Cell Press has provided permission for usage of this figure.]] | ||