Eric Martz's Favorites: Difference between revisions

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Eric Martz

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 ==Eric Martz's Favorites==
-* 2006 - Tamiflu bound to avian influenza neuraminidase N1, [[2hu4]] has tamiflu bound, while [[2hty]] lacks this ligand. Tamiflu was designed for N2/N9, not N1. Its antiviral activity via N1 is fortunate but surprising. Comparison of these two structures shows that tamiflu pulls N1 loop 147-152 into close contact, a case of "induced fit". Another surprise was a cavity near tamiflu that could serve as a target for designing better anti-avian influenza drugs.
+* 2006 - '''Tamiflu bound to avian influenza neuraminidase N1''', [[2hu4]] has tamiflu bound, while [[2hty]] lacks this ligand. Tamiflu was designed for N2/N9, not N1. Its antiviral activity via N1 is fortunate but surprising. Comparison of these two structures shows that tamiflu pulls N1 loop 147-152 into close contact, a case of "induced fit". Another surprise was a cavity near tamiflu that could serve as a target for designing better anti-avian influenza drugs.
-** a
+** [http://www.umass.edu/molvis/martz/lectures/labmolgen07/n1tami.htm  More background].
-** b
+** [http://www.umass.edu/molvis/martz/lectures/labmolgen07/index.htm  Lesson plan on this topic].
+** [http://www.umass.edu/molvis/martz/lectures/labmolgen07/index.htm#examples  Morphs of the induced fit].
+** [http://www.bioinformatics.org/jmol-tutorials/jtat/jtatdemo/ch_view2/chapter.htm  Cavity near tamiflu] is shown nicely in '''View 2''' of this chapter in a tutorial about developing tutorials using Jmol.