Hox protein: Difference between revisions
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===Homeodomain Architecture=== | ===Homeodomain Architecture=== | ||
Both Scr (yellow) and Exd (blue) belong to the family of homeodomain proteins, which are encoded by homeoboxes. <scene name='Sandbox_Reserved_169/Complex/1'>Homeodomains are helix-turn-helix motifs</scene> comprised of three alpha helices (Figure 3). The interface residues of both proteins are <scene name='Sandbox_Reserved_169/Complex/2'> evolutionary most conserved</scene> (dark purple vs. cyan).<br/> | Both Scr (yellow) and Exd (blue) belong to the family of homeodomain proteins, which are encoded by homeoboxes. <scene name='Sandbox_Reserved_169/Complex/1'>Homeodomains are helix-turn-helix motifs</scene> comprised of three alpha helices (Figure 3). The interface residues of both proteins are <scene name='Sandbox_Reserved_169/Complex/2'> evolutionary most conserved</scene> (dark purple for conserved residues vs. cyan for variable residues).<br/> | ||
Their third alpha helix of the Scr and Exd homeodomains, the so-called <scene name='Sandbox_Reserved_169/Scr_recognition_helix/3'>recognition helix</scene>, inserts into the major groove where hydrogen bonds are formed between protein side chains and base pairs. An N-terminal tail forms contacts with the minor groove.<br/> | Their third alpha helix of the Scr and Exd homeodomains, the so-called <scene name='Sandbox_Reserved_169/Scr_recognition_helix/3'>recognition helix</scene>, inserts into the major groove where hydrogen bonds are formed between protein side chains and base pairs. An N-terminal tail forms contacts with the minor groove.<br/> | ||