1gv7: Difference between revisions
New page: left|200px<br /> <applet load="1gv7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gv7, resolution 2.10Å" /> '''ARH-I, AN ANGIOGENI... |
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==About this Structure== | ==About this Structure== | ||
1GV7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens,_bos_taurus Homo sapiens, bos taurus]] with CIT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GV7 OCA]]. | 1GV7 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens,_bos_taurus Homo sapiens, bos taurus]] with CIT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GV7 OCA]]. | ||
==Reference== | ==Reference== | ||
Guest-host crosstalk in an angiogenin-RNase A chimeric protein., Holloway DE, Shapiro R, Hares MC, Leonidas DD, Acharya KR, Biochemistry. 2002 Aug 20;41(33):10482-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12173935 12173935] | Guest-host crosstalk in an angiogenin-RNase A chimeric protein., Holloway DE, Shapiro R, Hares MC, Leonidas DD, Acharya KR, Biochemistry. 2002 Aug 20;41(33):10482-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12173935 12173935] | ||
[[Category: Homo sapiens, bos taurus]] | [[Category: Homo sapiens, bos taurus]] | ||
[[Category: Pancreatic ribonuclease]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Acharya, K.R.]] | [[Category: Acharya, K.R.]] | ||
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[[Category: pancreatic ribonuclease]] | [[Category: pancreatic ribonuclease]] | ||
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Revision as of 14:23, 30 October 2007
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ARH-I, AN ANGIOGENIN/RNASE A CHIMERA
OverviewOverview
Angiogenin and ribonuclease A share 33% sequence identity but have, distinct functions. Angiogenin is a potent inducer of angiogenesis that is, only weakly ribonucleolytic, whereas ribonuclease A is a robust, ribonuclease that is not angiogenic. A chimera ("ARH-I"), in which, angiogenin residues 58-70 are replaced with residues 59-73 of ribonuclease, A, has intermediate ribonucleolytic potency and no angiogenic activity., Here we report a crystal structure of ARH-I that reveals the molecular, basis for these characteristics. The ribonuclease A-derived (guest), segment adopts a structure largely similar to that in ribonuclease A, and, successfully converts this region from a cell-binding site to a, purine-binding site. At the same time, its presence causes complex changes, in the ... [(full description)]
About this StructureAbout this Structure
1GV7 is a [Single protein] structure of sequence from [Homo sapiens, bos taurus] with CIT as [ligand]. Active as [Pancreatic ribonuclease], with EC number [3.1.27.5]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Guest-host crosstalk in an angiogenin-RNase A chimeric protein., Holloway DE, Shapiro R, Hares MC, Leonidas DD, Acharya KR, Biochemistry. 2002 Aug 20;41(33):10482-9. PMID:12173935
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