P53-DNA Recognition: Difference between revisions
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[[Image:p53-consensus.jpg|thumb|right|500px|Figure 2: p53 consensus site; R= A or G, Y= C or T, and W=A or T.]] | [[Image:p53-consensus.jpg|thumb|right|500px|Figure 2: p53 consensus site; R= A or G, Y= C or T, and W=A or T.]] | ||
[[Image:p53-domains.jpg|thumb|right|400px|Figure 3: p53 domains; N-ter=N-terminal, DBD=DNA binding domain, Tet=Tetramerization, and C-ter=C-terminal domain. Cancer mutants from [http://www-p53.iarc.fr/ IARC TP53 database]]] | [[Image:p53-domains.jpg|thumb|right|400px|Figure 3: p53 domains; N-ter=N-terminal, DBD=DNA binding domain, Tet=Tetramerization, and C-ter=C-terminal domain. Intermediate regions are fairly disordered. Cancer mutants from [http://www-p53.iarc.fr/ IARC TP53 database]]] | ||
Also known as the '''Guardian of the Genome''', the tumor suppressor p53 is central in the natural defense against human cancer. The protein is activated by stress factors that can compromise the genomic integrity of the cell, and this activation unleashes the function of p53 as transcription factor. It binds as a tetramer (Figure 1) to a large range of DNA response elements. The p53 consensus site (Figure 2) is formed by two decameric half-sites, each containing a core element (red), that are separated by a variable number of base pairs (blue). | Also known as the '''Guardian of the Genome''', the tumor suppressor p53 is central in the natural defense against human cancer. The protein is activated by stress factors that can compromise the genomic integrity of the cell, and this activation unleashes the function of p53 as transcription factor. It binds as a tetramer (Figure 1) to a large range of DNA response elements. The p53 consensus site (Figure 2) is formed by two decameric half-sites, each containing a core element (red), that are separated by a variable number of base pairs (blue). | ||