P53-DNA Recognition: Difference between revisions

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=A Base Pairing Variant Enhances p53 Binding to a Response Element=
=A Base Pairing Variant Enhances p53 Binding to a Response Element=


[[Image:p53-intro.jpg|thumb|left|300px|Crystal structure of p53-DNA complex; PDB ID# 3KZ8 (cite).]]
[[Image:p53-intro.jpg|thumb|left|300px|Figure 1: Crystal structure of a p53 DBD tetramer-DNA complex; PDB ID# 3KZ8 (cite).]]


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[[Image:p53-consensus.jpg|thumb|right|400px|consensus site]]
[[Image:p53-consensus.jpg|thumb|right|400px|consensus site]]


<Structure load='3kz8bio.pdb.zip' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />
<Structure load='3kz8bio.pdb.zip' size='500' frame='true' align='right' caption='Insert caption here' scene='Sandbox_Reserved_170/Complex/6' />


<scene name='Sandbox_Reserved_170/Complex/6'>Complex</scene>
<scene name='Sandbox_Reserved_170/Complex/6'>Complex</scene>

Revision as of 22:49, 3 July 2012

This Sandbox is Reserved from 22 April 2012, through 31 August 2012 for use in the course "Protein DNA" taught by Remo_Rohs at the La Canada High School, USA. This reservation includes Sandbox Reserved 169 through Sandbox Reserved 170.
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A Base Pairing Variant Enhances p53 Binding to a Response ElementA Base Pairing Variant Enhances p53 Binding to a Response Element

Figure 1: Crystal structure of a p53 DBD tetramer-DNA complex; PDB ID# 3KZ8 (cite).
domains
File:P53-consensus.jpg
consensus site

Insert caption here

Drag the structure with the mouse to rotate

domains
domains

Further ReadingFurther Reading

A more general discussion of structural origins of binding specificity in protein-DNA recognition has been published along with a suggestion for a new classification of protein-DNA readout modes that goes beyond the historical description of direct and indirect readout[1].

AcknowledgementsAcknowledgements

This Proteopedia page originates from the partnership of the Rohs Laboratory at the University of Southern California with La Canada High School. This partnership was initiated by Remo Rohs and Patty Compeau in September 2011 as Bioinformatics Institute, which is part of the Institutes of the 21st Century. Contributors to this page are USC graduate students Ana Carolina Dantas Machado, Proteopedia editor Eran Hodis, and La Canada High School students xxx. Research presented in this article has been conducted in the Shakked Lab at the Weizmann Institute of Science, the Rohs and L. Chen Labs at USC, and the Honig Lab at Columbia University. Furthermore, technical help by Proteopedia editors Eran Hodis, Eric Martz, Jaime Prilusky, and Joel Sussman is acknowledged.

ReferencesReferences

  1. ↑ Rohs R, Jin X, West SM, Joshi R, Honig B, Mann RS. Origins of specificity in protein-DNA recognition. Annu Rev Biochem. 2010;79:233-69.

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Jaime Prilusky, Remo Rohs, Bailey Holmes, Ana Carolina Dantas Machado, Eran Hodis, Julia Tam, Masha Karelina, Sharon Kim, Skyler Saleebyan, Keziah Kim, Joseph M. Steinberger, Eric Martz, Alexander Berchansky, Michal Harel, Angel Herraez, Joel L. Sussman
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