Phospholipase A2: Difference between revisions
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1yxh.png|left|200px|thumb|Crystal Structure of Phospholipase A2 from ''Naja naja sagittifera'' [[1yxh]]]] | [[Image:1yxh.png|left|200px|thumb|Crystal Structure of Phospholipase A2 from ''Naja naja sagittifera'' [[1yxh]]]] | ||
{{STRUCTURE_1yxh| PDB=1yxh | SIZE= | {{STRUCTURE_1yxh| PDB=1yxh | SIZE=400| SCENE=Phospholipase_A2/Cv/1 |right|CAPTION=Phospholipase A2 from ''Naja naja sagittifera'' complex with phosphate, ethanol, Ca+2 ion [[1yxh]] }} | ||
[[Phospholipase A2]] (PLA2) is an enzyme which releases fatty acids from glycerol. It is found in mammals and in snake venoms. PLA2 releases arachidonic acid from membranes causing inflammation and pain. PLA2 from the snake ''Bothrops jararacussu'' is called '''bothropstoxin (BTX)''' and from ''Bothrops pirajai'' – '''piratoxin (PTX)'''. The '''viperotoxin (VTX)''' is a heterodimer of very homologous PLA2 called '''RV-4/RV-7'''. The intracellular PLA2 – '''cystolic PLA2 (cPLA2)''' – are larger than the secreted PLA2 and contains the targeting C2 domain. The '''pro-phosphlipase (PPLA2)''' is a pancreatic PLA2 whose 7-mer N-terminal peptide is being cleaved off to produce the active PLA2. The PLA2 contains many isozymes which are ordered by groups and named accordingly, ie., group I is PLA2G1. The images at the left and at the right correspond to one representative PLA2, ''i.e.'' the crystal structure of Phospholipase A2 from ''Naja naja sagittifera'' ([[1yxh]]). | [[Phospholipase A2]] (PLA2) is an enzyme which releases fatty acids from glycerol. It is found in mammals and in snake venoms. PLA2 releases arachidonic acid from membranes causing inflammation and pain. PLA2 from the snake ''Bothrops jararacussu'' is called '''bothropstoxin (BTX)''' and from ''Bothrops pirajai'' – '''piratoxin (PTX)'''. The '''viperotoxin (VTX)''' is a heterodimer of very homologous PLA2 called '''RV-4/RV-7'''. The intracellular PLA2 – '''cystolic PLA2 (cPLA2)''' – are larger than the secreted PLA2 and contains the targeting C2 domain. The '''pro-phosphlipase (PPLA2)''' is a pancreatic PLA2 whose 7-mer N-terminal peptide is being cleaved off to produce the active PLA2. The PLA2 contains many isozymes which are ordered by groups and named accordingly, ie., group I is PLA2G1. The images at the left and at the right correspond to one representative PLA2, ''i.e.'' the crystal structure of Phospholipase A2 from ''Naja naja sagittifera'' ([[1yxh]]). | ||
| Line 8: | Line 8: | ||
== 3D Structures of Phospholipase A2 == | == 3D Structures of Phospholipase A2 == | ||
''Updated | ''Updated June 2012'' | ||
| Line 39: | Line 39: | ||
[[1a3d]], [[1a3f]], [[1ln8]], [[1mh2]], [[1mh8]], [[1ows]], [[1poa]], [[1psh]], [[1s6b]], [[1sz8]], [[1xxw]], [[1y75]], [[1yxl]], [[1yxh]] – PLA2 – ''Naja naja''<br /> | [[1a3d]], [[1a3f]], [[1ln8]], [[1mh2]], [[1mh8]], [[1ows]], [[1poa]], [[1psh]], [[1s6b]], [[1sz8]], [[1xxw]], [[1y75]], [[1yxl]], [[1yxh]] – PLA2 – ''Naja naja''<br /> | ||
[[2osh]] – PLA2 – Chinese cobra<br /> | [[2osh]] – PLA2 – Chinese cobra<br /> | ||
[[1ae7]], [[2not]] – PLA2 – ''Notechis scutatus''<br /> | [[1ae7]], [[2not]], [[4e4c]] – PLA2 – ''Notechis scutatus''<br /> | ||
[[1aok]], [[1jlt]], [[1q5t]], [[1rgb]], [[3dih]], [[3g8g]], [[3g8h]] – PLA2 – Vipera ammodytes<br /> | [[1aok]], [[1jlt]], [[1q5t]], [[1rgb]], [[3dih]], [[3g8g]], [[3g8h]] – PLA2 – Vipera ammodytes<br /> | ||
[[2i0u]] – PLA2 – ''Vipera nikolskii''<br /> | [[2i0u]] – PLA2 – ''Vipera nikolskii''<br /> | ||
| Line 60: | Line 60: | ||
[[3fvi]], [[3fvj]] – pPLA2G1B+octyl sulfate<br /> | [[3fvi]], [[3fvj]] – pPLA2G1B+octyl sulfate<br /> | ||
[[3qlm]] - pPLA2G1B + hexadecanoic acid<br /> | [[3qlm]] - pPLA2G1B + hexadecanoic acid<br /> | ||
[[3l30]], [[3l69]], [[3tt5]] - pPLA2G1B+berberine derivative<br /> | [[3l30]], [[3l69]], [[3tt5]], [[4dbk]] - pPLA2G1B+berberine derivative<br /> | ||
[[3osh]] – NnPLA2G1+atropin | [[3osh]] – NnPLA2G1+atropin | ||
| Line 126: | Line 126: | ||
[[2pmj]] – DrPLA2+benzopyrone<br /> | [[2pmj]] – DrPLA2+benzopyrone<br /> | ||
[[2zbh]] – DrPLA2+bavachalcone<br /> | [[2zbh]] – DrPLA2+bavachalcone<br /> | ||
[[4eix]] - DrPLA2+indomethacin + nimesulide<br /> | |||
[[1po8]], [[1tc8]] – kPLA2+fatty acid<br /> | [[1po8]], [[1tc8]] – kPLA2+fatty acid<br /> | ||
[[1xxs]] – PLA2+fatty acid – ''Bothrops moojeni''<br /> | [[1xxs]] – PLA2+fatty acid – ''Bothrops moojeni''<br /> | ||