2j05: Difference between revisions
New page: left|200px<br /> <applet load="2j05" size="450" color="white" frame="true" align="right" spinBox="true" caption="2j05, resolution 1.50Å" /> '''CRYSTAL STRUCTURE O... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:2j05. | [[Image:2j05.jpg|left|200px]]<br /><applet load="2j05" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2j05" size=" | |||
caption="2j05, resolution 1.50Å" /> | caption="2j05, resolution 1.50Å" /> | ||
'''CRYSTAL STRUCTURE OF THE RASGAP SH3 DOMAIN AT 1.5 ANGSTROM RESOLUTION'''<br /> | '''CRYSTAL STRUCTURE OF THE RASGAP SH3 DOMAIN AT 1.5 ANGSTROM RESOLUTION'''<br /> | ||
| Line 11: | Line 10: | ||
==About this Structure== | ==About this Structure== | ||
2J05 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 2J05 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J05 OCA]. | ||
==Reference== | ==Reference== | ||
| Line 31: | Line 30: | ||
[[Category: src homology 3]] | [[Category: src homology 3]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:36:54 2008'' | ||
Revision as of 18:36, 15 February 2008
|
CRYSTAL STRUCTURE OF THE RASGAP SH3 DOMAIN AT 1.5 ANGSTROM RESOLUTION
OverviewOverview
X-ray structures of two crystal forms of the Src homology 3 domain (SH3), of the Ras GTPase activating protein (RasGAP) were determined at 1.5 and, 1.8A resolution. The overall structure comprises a single domain with two, tightly packed beta-sheets linked by a short helical segment. An important, motif for peptide binding in other SH3 domains is not conserved in RasGAP., The RasGAP SH3 domain forms dimers in the crystal structures, which may, provide new functional insight. The dimer interface involves residues also, present in a peptide previously identified as an apoptotic sensitizer of, tumor cells.
DiseaseDisease
Known diseases associated with this structure: Basal cell carcinoma, somatic OMIM:[139150], Capillary malformation-arteriovenous malformation OMIM:[139150], Parkes Weber syndrome OMIM:[139150]
About this StructureAbout this Structure
2J05 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
High resolution crystal structures of the p120 RasGAP SH3 domain., Ross B, Kristensen O, Favre D, Walicki J, Kastrup JS, Widmann C, Gajhede M, Biochem Biophys Res Commun. 2007 Feb 9;353(2):463-8. Epub 2006 Dec 18. PMID:17188236
Page seeded by OCA on Fri Feb 15 17:36:54 2008