2hth: Difference between revisions
New page: left|200px<br /> <applet load="2hth" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hth, resolution 2.70Å" /> '''Structural basis fo... |
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[[Image:2hth. | [[Image:2hth.jpg|left|200px]]<br /><applet load="2hth" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2hth" size=" | |||
caption="2hth, resolution 2.70Å" /> | caption="2hth, resolution 2.70Å" /> | ||
'''Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain'''<br /> | '''Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain'''<br /> | ||
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==Overview== | ==Overview== | ||
The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into, vesicles that accumulate within multivesicular bodies (MVBs)., Crystallographic and biochemical analyses reveal that the GLUE domain of, the human ESCRT-II EAP45 (also called VPS36) subunit is a split, pleckstrin-homology domain that binds ubiquitin along one edge of the, beta-sandwich. The structure suggests how human ESCRT-II can couple, recognition of ubiquitinated cargoes and endosomal phospholipids during, MVB protein sorting. | The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into, vesicles that accumulate within multivesicular bodies (MVBs)., Crystallographic and biochemical analyses reveal that the GLUE domain of, the human ESCRT-II EAP45 (also called VPS36) subunit is a split, pleckstrin-homology domain that binds ubiquitin along one edge of the, beta-sandwich. The structure suggests how human ESCRT-II can couple, recognition of ubiquitinated cargoes and endosomal phospholipids during, MVB protein sorting. | ||
==Disease== | |||
Known disease associated with this structure: Cleft palate, isolated OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191339 191339]] | |||
==About this Structure== | ==About this Structure== | ||
2HTH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 2HTH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTH OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: viral budding]] | [[Category: viral budding]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:33:36 2008'' | ||
