3fxi: Difference between revisions

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{{Seed}}
[[Image:3fxi.png|left|200px]]
[[Image:3fxi.png|left|200px]]


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{{ABSTRACT_PUBMED_19252480}}
{{ABSTRACT_PUBMED_19252480}}


==Disease==
==About this Structure==
Known disease associated with this structure: Endotoxin hyporesponsiveness OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603030 603030]], Colorectal cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603030 603030]], Longevity, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603030 603030]], Macular degeneration, age-related, 10 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603030 603030]]
[[3fxi]] is a 4 chain structure of [[Toll-like Receptors]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The November 2011 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Toll-like Receptors''  by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2011_11 10.2210/rcsb_pdb/mom_2011_11]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FXI OCA].


==About this Structure==
==See Also==
3FXI is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FXI OCA].
*[[Toll-like Receptors|Toll-like Receptors]]


==Reference==
==Reference==
<ref group="xtra">PMID:19252480</ref><references group="xtra"/>
<ref group="xtra">PMID:019252480</ref><ref group="xtra">PMID:020485341</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Toll-like Receptors]]
[[Category: Kim, H M.]]
[[Category: Kim, H M.]]
[[Category: Lee, J O.]]
[[Category: Lee, J O.]]
[[Category: Park, B S.]]
[[Category: Park, B S.]]
[[Category: Song, D H.]]
[[Category: Song, D H.]]
[[Category: Alternative splicing]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Immune response]]
[[Category: Immune response]]
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[[Category: Leucine rich repeat]]
[[Category: Leucine rich repeat]]
[[Category: Membrane]]
[[Category: Membrane]]
[[Category: Polymorphism]]
[[Category: Receptor]]
[[Category: Receptor]]
[[Category: Secreted]]
[[Category: Secreted]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 10 22:12:40 2009''

Revision as of 09:51, 20 June 2012

File:3fxi.png

Template:STRUCTURE 3fxi

Crystal structure of the human TLR4-human MD-2-E.coli LPS Ra complexCrystal structure of the human TLR4-human MD-2-E.coli LPS Ra complex

Template:ABSTRACT PUBMED 19252480

About this StructureAbout this Structure

3fxi is a 4 chain structure of Toll-like Receptors with sequence from Escherichia coli and Homo sapiens. The November 2011 RCSB PDB Molecule of the Month feature on Toll-like Receptors by David Goodsell is 10.2210/rcsb_pdb/mom_2011_11. Full crystallographic information is available from OCA.

See AlsoSee Also

ReferenceReference

[xtra 1][xtra 2]

  1. Park BS, Song DH, Kim HM, Choi BS, Lee H, Lee JO. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature. 2009 Apr 30;458(7242):1191-5. Epub 2009 Mar 1. PMID:19252480 doi:10.1038/nature07830
  2. Lin SC, Lo YC, Wu H. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature. 2010 Jun 17;465(7300):885-90. Epub 2010 May 19. PMID:20485341 doi:10.1038/nature09121

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