2hhm: Difference between revisions
New page: left|200px<br /> <applet load="2hhm" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hhm, resolution 2.1Å" /> '''STRUCTURE OF INOSITO... |
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'''STRUCTURE OF INOSITOL MONOPHOSPHATASE, THE PUTATIVE TARGET OF LITHIUM THERAPY'''<br /> | '''STRUCTURE OF INOSITOL MONOPHOSPHATASE, THE PUTATIVE TARGET OF LITHIUM THERAPY'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2HHM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 and GD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] Full crystallographic information is available from [http:// | 2HHM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=GD:'>GD</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Inositol-phosphate_phosphatase Inositol-phosphate phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.25 3.1.3.25] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HHM OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: hydrolase]] | [[Category: hydrolase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:32:18 2008'' | ||
Revision as of 18:32, 15 February 2008
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STRUCTURE OF INOSITOL MONOPHOSPHATASE, THE PUTATIVE TARGET OF LITHIUM THERAPY
OverviewOverview
Inositol monophosphatase (EC 3.1.3.25), the putative molecular site of, action of lithium therapy for manic-depressive illness, plays a key role, in the phosphatidylinositol signaling pathway by catalyzing the hydrolysis, of inositol monophosphates. To provide a structural basis from which to, design better therapeutic agents for manic-depressive illness, the, structure of human inositol monophosphatase has been determined to 2.1-A, resolution by using x-ray crystallography. The enzyme exists as a dimer of, identical subunits, each folded into a five-layered sandwich of three, pairs of alpha-helices and two beta-sheets. Sulfate and an inhibitory, lanthanide cation (Gd3+) are bound at identical sites on each subunit and, establish the positions of the active sites. Each site is located in a, large hydrophilic cavern that is at the base of the two central helices, where several segments of secondary structure intersect. Comparison of the, phosphatase aligned sequences of several diverse genes with the, phosphatase structure suggests that the products of these genes and the, phosphatase form a structural family with a conserved metal binding site.
About this StructureAbout this Structure
2HHM is a Single protein structure of sequence from Homo sapiens with and as ligands. Active as Inositol-phosphate phosphatase, with EC number 3.1.3.25 Full crystallographic information is available from OCA.
ReferenceReference
Structure of inositol monophosphatase, the putative target of lithium therapy., Bone R, Springer JP, Atack JR, Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10031-5. PMID:1332026
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