2gwo: Difference between revisions
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'''crystal structure of TMDP'''<br /> | '''crystal structure of TMDP'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2GWO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 2GWO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GWO OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: alpha/beta]] | [[Category: alpha/beta]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:29:15 2008'' | ||
Revision as of 18:29, 15 February 2008
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crystal structure of TMDP
OverviewOverview
The testis- and skeletal-muscle-specific dual-specificity phosphatase, (TMDP) is a member of the dual-specificity phosphatase (DSP) subgroup of, protein tyrosine phosphatases. TMDP has similar activities toward both, tyrosine and threonine phosphorylated substrates, and is supposed to be, involved in spermatogenesis. Here, we report the crystal structure of, human TMDP at a resolution of 2.4 A. In spite of high sequence similarity, with other DSPs, the crystal structure of TMDP shows distinct structural, motifs and surface properties. In TMDP, the alpha1-beta1 loop, a substrate, recognition motif is located further away from the active site loop in, comparison to prototype DSP Vaccinia H1 related phophatase (VHR), which, preferentially dephosphorylates tyrosine phosphorylated substrates and, down-regulates MAP kinase signaling. Residues in the active site residues, of TMDP are smaller in size and more hydrophobic than those of VHR. In, addition, TMDP cannot be aligned with VHR in loop beta3-alpha4. These, differences in the active site of TMDP result in a flat and wide pocket, structure, allowing equal binding of phosphotyrosine and phosphothreonine, substrates.
About this StructureAbout this Structure
2GWO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity., Kim SJ, Jeong DG, Yoon TS, Son JH, Cho SK, Ryu SE, Kim JH, Proteins. 2007 Jan 1;66(1):239-45. PMID:17044055
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