Fibronectin: Difference between revisions
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[[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]] | [[Image:1fbr.png|left|200px|thumb|Crystal Structure of Fibronectin 4-5FnI fragment [[1fbr]]]] | ||
{{STRUCTURE_1fbr| PDB=1fbr | SIZE= | {{STRUCTURE_1fbr| PDB=1fbr | SIZE=400| SCENE=Fibronectin/Cv/1 |right|CAPTION=Fibronectin 4-5FnI fragment [[1fbr]] }} | ||
[[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment ([[1fbr]]). | [[Fibronectin]] (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. It is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., 6FnI+1-2FnII is the gelatin binding domain (GBD). The images at the left and at the right correspond to one representative Fn, ''i.e.'' the crystal structure of human Fibronectin 4-5FnI fragment ([[1fbr]]). | ||
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== 3D Structures of Fibronectin == | == 3D Structures of Fibronectin == | ||
''Update June 2012'' | |||
=== Fn module FnI === | === Fn module FnI === | ||
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[[1o9a]] - hFn 1-2FnI+B3 from FNBB – NMR<br /> | [[1o9a]] - hFn 1-2FnI+B3 from FNBB – NMR<br /> | ||
[[2ec3]] – hFn 11FnI – NMR<br /> | [[2ec3]] – hFn 11FnI – NMR<br /> | ||
[[3r8q]] – hFn 12-14FnI<br /> | |||
[[1qgb]] – hFn FnI N-terminal - NMR<br /> | [[1qgb]] – hFn FnI N-terminal - NMR<br /> | ||
[[2ck2]] – hFn (mutant) core swapped<br /> | [[2ck2]] – hFn (mutant) core swapped<br /> | ||