Factor Xa: Difference between revisions
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[[Image:Coagulation full.svg.png|thumb|450px|The coagulation cascade.]] | [[Image:Coagulation full.svg.png|thumb|450px|The coagulation cascade.]] | ||
==Introduction== | ==Introduction== | ||
'''Factor X''' is a vitamin K-dependent [http://en.wikipedia.org/wiki/Glycoprotein glycoprotein] that is synthesized in the liver. [http://en.wikipedia.org/wiki/Zymogen Zymogen] factor X circulates in plasma as a 2 chain molecule composed of a disulfide linked light chain (Mr = 16500) and heavy chain (Mr = 42,000). Factor X is activated to factor Xa by cleavage of the activation peptide. This reaction is catalyzed by [http://en.wikipedia.org/wiki/Factor_VIIa factor VIIa]-[http://en.wikipedia.org/wiki/Tissue_factor tissue factor] (extrinsic Xase complex) and [http://en.wikipedia.org/wiki/Factor_ixa factor IXa]-[http://en.wikipedia.org/wiki/Factor_viiia factor VIIIa] (intrinsic Xase complex).<ref name="Greer">Greer, John (2008). ''Wintrobe's Clinical Hematology'', p. 545-546. Lippincott Williams & Wilkins. ISBN 0781765072.</ref> | '''Factor X''' is a vitamin K-dependent [http://en.wikipedia.org/wiki/Glycoprotein glycoprotein] that is synthesized in the liver. [http://en.wikipedia.org/wiki/Zymogen Zymogen] factor X circulates in plasma as a 2 chain molecule composed of a disulfide linked light chain (Mr = 16500) and heavy chain (Mr = 42,000). Factor X is activated to '''factor Xa''' by cleavage of the activation peptide. This reaction is catalyzed by [http://en.wikipedia.org/wiki/Factor_VIIa factor VIIa]-[http://en.wikipedia.org/wiki/Tissue_factor tissue factor] (extrinsic Xase complex) and [http://en.wikipedia.org/wiki/Factor_ixa factor IXa]-[http://en.wikipedia.org/wiki/Factor_viiia factor VIIIa] (intrinsic Xase complex).<ref name="Greer">Greer, John (2008). ''Wintrobe's Clinical Hematology'', p. 545-546. Lippincott Williams & Wilkins. ISBN 0781765072.</ref> | ||
Factor Xa, along with [http://en.wikipedia.org/wiki/Factor_va factor Va], calcium, and a phospholipid membrane surface to form the [http://en.wikipedia.org/wiki/Prothrombinase prothrombinase complex], and cleave [http://en.wikipedia.org/wiki/Prothrombin prothrombin] to its active form, [http://en.wikipedia.org/wiki/Prothrombin thrombin].<ref name="Greer" /> | Factor Xa, along with [http://en.wikipedia.org/wiki/Factor_va factor Va], calcium, and a phospholipid membrane surface to form the [http://en.wikipedia.org/wiki/Prothrombinase prothrombinase complex], and cleave [http://en.wikipedia.org/wiki/Prothrombin prothrombin] to its active form, [http://en.wikipedia.org/wiki/Prothrombin thrombin].<ref name="Greer" /> | ||