DNA methyltransferase: Difference between revisions
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{{STRUCTURE_1qnt| PDB=1qnt | SIZE=400| SCENE= |right|CAPTION=Human O6-methylguanine DNA methyltransferase, [[1qnt]] }} | {{STRUCTURE_1qnt| PDB=1qnt | SIZE=400| SCENE= |right|CAPTION=Human O6-methylguanine DNA methyltransferase, [[1qnt]] }} | ||
'''DNA methyltransferase''' (DNMT) catalyzes the transfer of methyl group to DNA. DNMT uses S-adenosyl methionine (SAM) as the methyl donor. | '''DNA methyltransferase''' (DNMT) catalyzes the transfer of methyl group to DNA. DNMT uses S-adenosyl methionine (SAM) as the methyl donor. The SAM analog S-adenosyl homocysteine (SAH) is a powerful inhibitor of DNMT. | ||
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
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== 3D Structures of DNA methyltransferase == | == 3D Structures of DNA methyltransferase == | ||
''Updated | ''Updated June 2012'' | ||
===Methylguanine DNMT=== | ===Methylguanine DNMT=== | ||
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[[3a1a]] - h-cytosine DNMT PWWP domain | [[3a1a]] - h-cytosine DNMT PWWP domain | ||
[[1g55]] - h-cytosine DNMT2 (mutant) | [[1g55]] - h-cytosine DNMT2 (mutant)<br /> | ||
[[3qkj[[ - h-cytosine DNMT 3β<br /> | |||
[[3av4]], [[1khc]] - m-cytosine DNMT – mouse | [[3av4]], [[1khc]] - m-cytosine DNMT – mouse | ||
[[2uyc]], [[2uyh]], [[2uz4]] - Hh-cytosine DNMT (mutant) + DNA + SAH | |||
[[2uyc]], [[2uyh]], [[2uz4]] - Hh-cytosine DNMT (mutant) + DNA + | |||
[[3a1b]] - h-cytosine DNMT ADD domain + histone H3 | [[3a1b]] - h-cytosine DNMT ADD domain + histone H3 | ||
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[[3pt6]], [[3pt9]] – m-cytosine DNMT + DNA | [[3pt6]], [[3pt9]] – m-cytosine DNMT + DNA | ||
[[3av5]] - m-cytosine DNMT + | [[3av5]] - m-cytosine DNMT + SAH | ||
[[3av6]] - m-cytosine DNMT + SAM | [[3av6]] - m-cytosine DNMT + SAM | ||
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[[3swr]] - h-cytosine DNMT + sinefungin | [[3swr]] - h-cytosine DNMT + sinefungin | ||
[[1boo]] - cytosine DNMT (mutant) – ''Proteus vulgaris'' | [[1boo]] - cytosine DNMT (mutant) – ''Proteus vulgaris''<br /> | ||
[[3qv2]] - cytosine DNMT + SAH – ''Entamoeba histolytica''<br /> | |||
[[1fjx]] – | [[2uyc]], [[2uyh]], [[2uz4]], [[1fjx]] – Hh-cytosine DNMT (mutant) + DNA + SAH - ''Haemophilus haemolyticus''<br /> | ||
[[2c7o]], [[2c7p]], [[2c7q]], [[2c7r]], [[3pta]] – Hh-cytosine DNMT + DNA + S-adenonosyl cysteine<br /> | |||
[[ | [[1hmy]] – Hh-cytosine Haeiii DNMT + SAM | ||
[[1m0e]] - | [[1m0e]] - Hh-cytosine DNMT (mutant) + DNA + inhibitor | ||
[[2i9k]] - | [[2i9k]] - Hh-cytosine DNMT (mutant) + DNA | ||
[[2hr1]] - | [[2hr1]] - Hh-cytosine DNMT + DNA + ADOHCY | ||
[[2z6q]], [[2z6u]], [[2zcj]] - | [[2z6q]], [[2z6u]], [[2zcj]] - Hh-cytosine DNMT (mutant) + DNA + ADOHCY | ||
[[1svu]] - | [[1svu]] - Hh-cytosine DNMT (mutant) | ||
===Methyladenine DNMT=== | ===Methyladenine DNMT=== | ||
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[[1nw5]] – RsN6-adenine DNMT + SAM – ''Rhodobacter sphaeroides'' | [[1nw5]] – RsN6-adenine DNMT + SAM – ''Rhodobacter sphaeroides'' | ||
[[1nw6]] - RsN6-adenine DNMT + sinefungin | [[1nw6]] - RsN6-adenine DNMT + sinefungin<br /> | ||
[[1nw7]] - RsN6-adenine DNMT + SAH<br /> | |||
[[1nw8]] - RsN6-adenine DNMT (mutant) | |||
[[ | [[2ibs]], [[2ibt]], [[2ih2]], [[2ih4]], [[2ih5]], [[2np6]], [[2np7]], [[1g38]] - Ta-adenine DNMT Taqi + DNA + cofactor analog – ''Thermus aquaticus''<br /> | ||
[[1aqi]] – Ta-adenine DNMT Taqi + SAH<br /> | |||
[[1aqj]] – Ta-adenine DNMT Taqi + sinefugin<br /> | |||
[[2adm]] - Ta-adenine DNMT Taqi + SAM<br /> | |||
[[1g60]] - adenine DNMT + SAM – ''Moraxella bovis'' | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||