Sandbox SouthUniversity1: Difference between revisions

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{On what position(s) of the phenyl ring next to the heme might you expect this oxidation to take place?
{On what position(s) of the phenyl ring next to the heme might you expect this oxidation to take place?
|type="()"}
|type="()"}
+ The para position
+ The para position.
|| This is a valid assumption, based solely on the orientation of the substrate relative to the heme.
|| This is a valid assumption, based solely on the orientation of the substrate relative to the heme.
+ One of the meta positions.
- One of the meta positions.
|| This is a possibility, based solely on the orientation of the substrate relative to the heme.
|| This is a possibility, based solely on the orientation of the substrate relative to the heme. However, in this case other factors come into play, such as relative reactivity of the ortho, meta, and para positions.
- One of the ortho positions
- One of the ortho positions.
|| You would not expect this to be likely, based on the distance from the active iron center to either of the ortho positions.
|| You would not expect this to be likely, based on the distance from the active iron center to either of the ortho positions.
</quiz>
</quiz>


<quiz display=simple>
{Question
|type="()"}
+ The correct answer.
|| Feedback for correct answer.
- Distractor.
|| Feedback for distractor.
- Distractor.
|| Feedback for distractor.
- Distractor.
|| Feedback for distractor.
</quiz>


Different members of the CYP450 enzymes preferentially metabolize different xenobiotics. What features of a drug do you think might cause it to be metabolized by one CYP versus another?
Different members of the CYP450 enzymes preferentially metabolize different xenobiotics. What features of a drug do you think might cause it to be metabolized by one CYP versus another?

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Arthur Cox