Sandbox SouthUniversity1: Difference between revisions
Arthur Cox (talk | contribs) No edit summary |
Arthur Cox (talk | contribs) No edit summary |
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Now look at the substrate molecule being oxidized and view its orientation relative to the heme group by clicking <scene name='Sandbox_SouthUniversity1/Heme_and_flavone/3'>this link</scene> Resize and rotate the molecules until you can see how the two molecules are oriented in relationship to each other. The flavone is metabolized (oxidized) by introduction of a hydroxy group onto the phenyl ring that is attached to the tricyclic ring system. | Now look at the substrate molecule being oxidized and view its orientation relative to the heme group by clicking <scene name='Sandbox_SouthUniversity1/Heme_and_flavone/3'>this link</scene> Resize and rotate the molecules until you can see how the two molecules are oriented in relationship to each other. The flavone is metabolized (oxidized) by introduction of a hydroxy group onto the phenyl ring that is attached to the tricyclic ring system. | ||
Purely based on the distance between the pheny ring of the flavone substrate and the heme iron, oxidation might be expected to take place at the 4 (para) position. However, other factors also help determine the regioselectivity of the metabolism (selectivity for oxidation at the different possible positions). One of these factors is the relative reactivity of the various positions on the substrate. | |||
</StructureSection> | |||
<quiz display=simple> | <quiz display=simple> | ||
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|| You would not expect this to be likely, based on the distance from the active iron center to either of the ortho positions. | || You would not expect this to be likely, based on the distance from the active iron center to either of the ortho positions. | ||
</quiz> | </quiz> | ||
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+ The correct answer. | |||
|| Feedback for correct answer. | |||
- Distractor. | |||
|| Feedback for distractor. | |||
- Distractor. | |||
|| Feedback for distractor. | |||
- Distractor. | |||
|| Feedback for distractor. | |||
</quiz> | |||