Anum-II: Difference between revisions
New page: {{STRUCTURE_1mg6 | PDB=1mg6 | SCENE= }} == '''Introduction''' == Anum-II is a Lys49 Phospholipase A2 (<scene name='Sandbox136/Lys/1'>K49</scene>PLA2),protein extracted from [http... |
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<StructureSection load="1mg6" size="400" color="" frame="true" spin="on" Scene= align="right" caption= > | |||
== '''Introduction''' == | == '''Introduction''' == | ||
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Vascular endothelial growth factor (VEGF165) and its Kinase insert domain containing receptor (KDR) are used in mechanisms of regulations of blood vessel formations. Experiments have revealed that the venom extracted from ''Agkistrodon piscivorus'' contains a KDR binding protein.It has been shown that this KDRb-p was in fact a Lys49 PLA2.Lys49 is able to bind to the extracellular domain of KDR receptors with a sub-nanomolar affinity (Yamazaki ''et al.'', 2005). Studies revealed the fact that the region of the protein involved in the fixation on KDR was located in the C-terminal region (Chioato ''et al.'', 2002). C- terminal region differs from the rest of the protein in his amino acid sequence, indeed some amino-acids are positive (K,R) and seem to play a role in the recognition and fixation on KDR. | Vascular endothelial growth factor (VEGF165) and its Kinase insert domain containing receptor (KDR) are used in mechanisms of regulations of blood vessel formations. Experiments have revealed that the venom extracted from ''Agkistrodon piscivorus'' contains a KDR binding protein.It has been shown that this KDRb-p was in fact a Lys49 PLA2.Lys49 is able to bind to the extracellular domain of KDR receptors with a sub-nanomolar affinity (Yamazaki ''et al.'', 2005). Studies revealed the fact that the region of the protein involved in the fixation on KDR was located in the C-terminal region (Chioato ''et al.'', 2002). C- terminal region differs from the rest of the protein in his amino acid sequence, indeed some amino-acids are positive (K,R) and seem to play a role in the recognition and fixation on KDR. | ||
</StructureSection> | |||
== Bibliography == | == Bibliography == | ||
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Yamazaki, Y., Matsunaga, Y., Nakano, Y. & Morita, T. (2005). ''J. Biol. Chem''. '''280''', 29989–29992. | Yamazaki, Y., Matsunaga, Y., Nakano, Y. & Morita, T. (2005). ''J. Biol. Chem''. '''280''', 29989–29992. | ||
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Created with the participation of [[User:Elie Peillon|Elie Peillon]] | |||
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