2a3d: Difference between revisions
New page: left|200px<br /> <applet load="2a3d" size="450" color="white" frame="true" align="right" spinBox="true" caption="2a3d" /> '''SOLUTION STRUCTURE OF A DE NOVO DESIGNED SI... |
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'''SOLUTION STRUCTURE OF A DE NOVO DESIGNED SINGLE CHAIN THREE-HELIX BUNDLE (A3D)'''<br /> | '''SOLUTION STRUCTURE OF A DE NOVO DESIGNED SINGLE CHAIN THREE-HELIX BUNDLE (A3D)'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
2A3D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The following page contains interesting information on the relation of 2A3D with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http:// | 2A3D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. The following page contains interesting information on the relation of 2A3D with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3D OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: three-helix bundle]] | [[Category: three-helix bundle]] | ||
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Revision as of 18:13, 15 February 2008
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SOLUTION STRUCTURE OF A DE NOVO DESIGNED SINGLE CHAIN THREE-HELIX BUNDLE (A3D)
OverviewOverview
Although de novo protein design is an important endeavor with implications, for understanding protein folding, until now, structures have been, determined for only a few 25- to 30-residue designed miniproteins. Here, the NMR solution structure of a complex 73-residue three-helix bundle, protein, alpha3D, is reported. The structure of alpha3D was not based on, any natural protein, and yet it shows thermodynamic and spectroscopic, properties typical of native proteins. A variety of features contribute to, its unique structure, including electrostatics, the packing of a diverse, set of hydrophobic side chains, and a loop that incorporates common, capping motifs. Thus, it is now possible to design a complex protein with, a well defined and predictable three-dimensional structure.
About this StructureAbout this Structure
2A3D is a Protein complex structure of sequences from Escherichia coli. The following page contains interesting information on the relation of 2A3D with [Designer Proteins]. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure and dynamics of a de novo designed three-helix bundle protein., Walsh ST, Cheng H, Bryson JW, Roder H, DeGrado WF, Proc Natl Acad Sci U S A. 1999 May 11;96(10):5486-91. PMID:10318910
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