1yt9: Difference between revisions
New page: left|200px<br /> <applet load="1yt9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1yt9, resolution 3.00Å" /> '''HIV Protease with o... |
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[[Image:1yt9. | [[Image:1yt9.jpg|left|200px]]<br /><applet load="1yt9" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1yt9, resolution 3.00Å" /> | caption="1yt9, resolution 3.00Å" /> | ||
'''HIV Protease with oximinoarylsulfonamide bound'''<br /> | '''HIV Protease with oximinoarylsulfonamide bound'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1YT9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with OIS as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1YT9 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1] with <scene name='pdbligand=OIS:'>OIS</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YT9 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: oximinoarylsulfonamides]] | [[Category: oximinoarylsulfonamides]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:12:30 2008'' | ||
Revision as of 18:12, 15 February 2008
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HIV Protease with oximinoarylsulfonamide bound
OverviewOverview
The need for a potent HIV protease inhibitor (PI) to combat emerging, PI-resistant viruses is anticipated. Analogs formulated from the, combination of structural fragments of Ritonavir, Lopinavir, and, Amprenavir were synthesized. Analogs containing the oxime pharmacophore, were found to have improved activities against both wild type and, resistant (A17) viruses. The synthesis and structure-activity, relationships (SAR) based upon the in vitro IC50 of this series of, compounds are reported.
About this StructureAbout this Structure
1YT9 is a Single protein structure of sequence from Human immunodeficiency virus 1 with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Oximinoarylsulfonamides as potent HIV protease inhibitors., Yeung CM, Klein LL, Flentge CA, Randolph JT, Zhao C, Sun M, Dekhtyar T, Stoll VS, Kempf DJ, Bioorg Med Chem Lett. 2005 May 2;15(9):2275-8. PMID:15837308
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