1a5t: Difference between revisions
New page: left|200px<br /> <applet load="1a5t" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a5t, resolution 2.2Å" /> '''CRYSTAL STRUCTURE OF... |
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==About this Structure== | ==About this Structure== | ||
1A5T is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A5T OCA]]. | 1A5T is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]] with ZN as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7]]. Structure known Active Site: ZNB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1A5T OCA]]. | ||
==Reference== | ==Reference== | ||
Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III., Guenther B, Onrust R, Sali A, O'Donnell M, Kuriyan J, Cell. 1997 Oct 31;91(3):335-45. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9363942 9363942] | Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III., Guenther B, Onrust R, Sali A, O'Donnell M, Kuriyan J, Cell. 1997 Oct 31;91(3):335-45. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9363942 9363942] | ||
[[Category: DNA-directed DNA polymerase]] | |||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: zinc finger]] | [[Category: zinc finger]] | ||
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Revision as of 14:15, 30 October 2007
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CRYSTAL STRUCTURE OF THE DELTA PRIME SUBUNIT OF THE CLAMP-LOADER COMPLEX OF ESCHERICHIA COLI DNA POLYMERASE III
OverviewOverview
The crystal structure of the delta' subunit of the clamp-loader complex of, E. coli DNA polymerase III has been determined. Three consecutive domains, in the structure are arranged in a C-shaped architecture. The N-terminal, domain contains a nonfunctional nucleotide binding site. The catalytic, component of the clamp-loader complex is the gamma subunit, which is, homologous to delta'. A sequence-structure alignment suggests that, nucleotides bind to gamma at an interdomain interface within the inner, surface of the "C." The alignment is extended to other clamp-loader, complexes and to the RuvB family of DNA helicases, and suggests that each, of these is assembled from C-shaped components that can open and close the, jaws of the "C" in response to ATP binding and hydrolysis.
About this StructureAbout this Structure
1A5T is a [Single protein] structure of sequence from [Escherichia coli] with ZN as [ligand]. Active as [DNA-directed DNA polymerase], with EC number [2.7.7.7]. Structure known Active Site: ZNB. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III., Guenther B, Onrust R, Sali A, O'Donnell M, Kuriyan J, Cell. 1997 Oct 31;91(3):335-45. PMID:9363942
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