Annexin: Difference between revisions
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{{STRUCTURE_1ain| PDB=1ain | SIZE=400| SCENE=Annexin/Cv/2 |right|CAPTION=Human Annexin I complex with Ca+2 ions, [[1ain]] }} | {{STRUCTURE_1ain| PDB=1ain | SIZE=400| SCENE=Annexin/Cv/2 |right|CAPTION=Human Annexin I complex with Ca+2 ions, [[1ain]] }} | ||
[[Annexin|Annexins]] are proteins which make a membrane scaffold. They bind negatively charged phospholipids and contain a 70 amino acid long annexin repeat. They consist of 2 domains - the C-terminal core and the N-terminal head. Annexins divide into species and are numbered from I to XII. Annexin V is the most abundant scaffolding protein. In the annexin image calcium ions are shown as green balls. | [[Annexin|Annexins]] are proteins which make a membrane scaffold. They bind negatively charged phospholipids and contain a 70 amino acid long annexin repeat. They consist of 2 domains - the C-terminal core and the N-terminal head. Annexins divide into species and are numbered from I to XII. Annexin V is the most abundant scaffolding protein. Annexin E1 (AnE1) is associated with tubulin in trophozoites of ''Giardia lamblia'' and forms local slubs in the flagella. In the annexin image calcium ions are shown as green balls. | ||
==3D structures of annexin== | ==3D structures of annexin== | ||
''Update | ''Update May 2012'' | ||
== Annexin I == | == Annexin I == | ||
[[2q4c]], [[1ycn]] - AnI - ''Arabidopsis thaliana''<br /> | [[2q4c]], [[1ycn]] - AnI - ''Arabidopsis thaliana''<br /> | ||
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[[1bo9]] - hAnI head - human NMR<br /> | [[1bo9]] - hAnI head - human NMR<br /> | ||
[[1ain]] - hAnI<br /> | [[1ain]] - hAnI<br /> | ||
== Annexin II == | == Annexin II == | ||
[[2hyu]], [[2hyv]] - hAnII+heparin oligosaccharide<br /> | [[2hyu]], [[2hyv]] - hAnII+heparin oligosaccharide<br /> | ||
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[[1w7b]] - hAnII<br /> | [[1w7b]] - hAnII<br /> | ||
[[1bt6]] - hAnII head+calpactin light chain<br /> | [[1bt6]] - hAnII head+calpactin light chain<br /> | ||
== Annexin III == | == Annexin III == | ||
[[1aii]], [[1axn]] - hAnIII<br /> | [[1aii]], [[1axn]] - hAnIII<br /> | ||
== Annexin IV == | == Annexin IV == | ||
[[2zhi]], [[2zhj]], rAnIV+Na - rat<br /> | [[2zhi]], [[2zhj]], rAnIV+Na - rat<br /> | ||
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[[1i4a]] - cAnIV (mutant) - cow<br /> | [[1i4a]] - cAnIV (mutant) - cow<br /> | ||
[[1aow]], [[1ann]] - cAnIV<br /> | [[1aow]], [[1ann]] - cAnIV<br /> | ||
== Annexin V == | == Annexin V == | ||
[[2ie6]], [[2ie7]], rAnV<br /> | [[2ie6]], [[2ie7]], rAnV<br /> | ||
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[[2xo2]] – hAnV + Ca + azidohomoalanine<br /> | [[2xo2]] – hAnV + Ca + azidohomoalanine<br /> | ||
[[2xo3]] - hAnV + Ca + homopropargylglycine | [[2xo3]] - hAnV + Ca + homopropargylglycine | ||
== Annexin VI == | == Annexin VI == | ||
[[1m9i]] - hAnVI (mutant)<br /> | [[1m9i]] - hAnVI (mutant)<br /> | ||
[[1avc]] - cAnVI+Ca<br /> | [[1avc]] - cAnVI+Ca<br /> | ||
== Annexin VIII == | == Annexin VIII == | ||
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[[1w3w]] - hAnVIII<br /> | [[1w3w]] - hAnVIII<br /> | ||
[[1w45]] - hAnVIII (mutant)<br /> | [[1w45]] - hAnVIII (mutant)<br /> | ||
== Annexin XII == | == Annexin XII == | ||
[[1dm5]] - HvAnXII (mutant) - ''Hydra vulgaris''<br /> | [[1dm5]] - HvAnXII (mutant) - ''Hydra vulgaris''<br /> | ||
[[1aei]] - HvAnXII<br /> | [[1aei]] - HvAnXII<br /> | ||
== Annexin E1 == | |||
[[3chj]] – GlAnE1 – ''Giardia lamblia''<br /> | |||
[[3chk]], [[3chl]] – GlAnE1 + cation | |||
== Other annexins == | == Other annexins == | ||
[[1dk5]] - An24 - ''Capsicom annuum''<br /> | [[1dk5]] - An24 - ''Capsicom annuum''<br /> | ||