1ttt: Difference between revisions
New page: left|200px<br /> <applet load="1ttt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ttt, resolution 2.7Å" /> '''PHE-TRNA, ELONGATION... |
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[[Image:1ttt. | [[Image:1ttt.jpg|left|200px]]<br /><applet load="1ttt" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''PHE-TRNA, ELONGATION FACTOR EF-TU:GDPNP TERNARY COMPLEX'''<br /> | '''PHE-TRNA, ELONGATION FACTOR EF-TU:GDPNP TERNARY COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1TTT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus] with MG and GNP as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1TTT with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb81_1.html Elongation Factors]]. Full crystallographic information is available from [http:// | 1TTT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_aquaticus Thermus aquaticus] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=GNP:'>GNP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1TTT with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb81_1.html Elongation Factors]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TTT OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: trna]] | [[Category: trna]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:58:27 2008'' | ||
Revision as of 17:58, 15 February 2008
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PHE-TRNA, ELONGATION FACTOR EF-TU:GDPNP TERNARY COMPLEX
OverviewOverview
The structure of the ternary complex consisting of yeast, phenylalanyl-transfer RNA (Phe-tRNAPhe), Thermus aquaticus elongation, factor Tu (EF-Tu), and the guanosine triphosphate (GTP) analog GDPNP was, determined by x-ray crystallography at 2.7 angstrom resolution. The, ternary complex participates in placing the amino acids in their correct, order when messenger RNA is translated into a protein sequence on the, ribosome. The EF-Tu-GDPNP component binds to one side of the acceptor, helix of Phe-tRNAPhe involving all three domains of EF-Tu. Binding sites, for the phenylalanylated CCA end and the phosphorylated 5' end are located, at domain interfaces, whereas the T stem interacts with the surface of the, beta-barrel domain 3. The binding involves many conserved residues in, EF-Tu. The overall shape of the ternary complex is similar to that of the, translocation factor, EF-G-GDP, and this suggests a novel mechanism, involving "molecular mimicry" in the translational apparatus.
About this StructureAbout this Structure
1TTT is a Single protein structure of sequence from Thermus aquaticus with and as ligands. The following page contains interesting information on the relation of 1TTT with [Elongation Factors]. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog., Nissen P, Kjeldgaard M, Thirup S, Polekhina G, Reshetnikova L, Clark BF, Nyborg J, Science. 1995 Dec 1;270(5241):1464-72. PMID:7491491
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