Lipase lid morph: Difference between revisions
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For an introduction to the structure and function of lipase, please see the article [[Lipase]]. This ''Lipase lid morph'' article is a supplement to the main article on [[Lipase]]. | For an introduction to the structure and function of lipase, please see the article [[Lipase]]. This ''Lipase lid morph'' article is a supplement to the main article on [[Lipase]]. | ||
''Candida rugosa'' lipase (triacylglycerol hydrolase) has been observed in two conformations, with the "lid" closed ([[1trh]]) or open ([[1lpm]])<ref name='2states1994'>PMID: 8142901</ref>. A <scene name='Lipase_lid_morph/Rainbow/2'>morph</scene><ref>This is a [[Morphs#Linear_Interpolation|linear interpolation morph]]. The 14-model PDB file is [[Image:Morph-linear-1trh-1lpm.pdb.gz]].</ref> shows the lid opening and closing. | ''Candida rugosa'' lipase (triacylglycerol hydrolase) has been observed in two conformations, with the "lid" closed ([[1trh]]) or open ([[1lpm]])<ref name='2states1994'>PMID: 8142901</ref>. | ||
* <scene name='Lipase_lid_morph/Lightseagreen_hinge/1'>Closed</scene> <font color='lightseagreen'><b>LID</b></font>. | |||
A <scene name='Lipase_lid_morph/Rainbow/2'>morph</scene><ref>This is a [[Morphs#Linear_Interpolation|linear interpolation morph]]. The 14-model PDB file is [[Image:Morph-linear-1trh-1lpm.pdb.gz]].</ref> shows the lid opening and closing. | |||
When open, substrate can access the catalytic triad, Ser209, Glu341, and His449<ref name='2states1994' /> | When open, substrate can access the catalytic triad, Ser209, Glu341, and His449<ref name='2states1994' /> | ||
Revision as of 14:03, 14 May 2012
For an introduction to the structure and function of lipase, please see the article Lipase. This Lipase lid morph article is a supplement to the main article on Lipase.
Candida rugosa lipase (triacylglycerol hydrolase) has been observed in two conformations, with the "lid" closed (1trh) or open (1lpm)[1].
- LID.
A [2] shows the lid opening and closing.
When open, substrate can access the catalytic triad, Ser209, Glu341, and His449[1]
See AlsoSee Also
- Lipase, the main article in Proteopedia.
- Molecular Playground/Pancreatic Lipase
- Lipase in Wikipedia
Notes and ReferencesNotes and References
- ↑ 1.0 1.1 Grochulski P, Li Y, Schrag JD, Cygler M. Two conformational states of Candida rugosa lipase. Protein Sci. 1994 Jan;3(1):82-91. PMID:8142901
- ↑ This is a linear interpolation morph. The 14-model PDB file is File:Morph-linear-1trh-1lpm.pdb.gz.