1ux6: Difference between revisions
New page: left|200px<br /> <applet load="1ux6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ux6, resolution 1.90Å" /> '''STRUCTURE OF A THRO... |
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==About this Structure== | ==About this Structure== | ||
1UX6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UX6 OCA]]. | 1UX6 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UX6 OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: l-type lectin]] | [[Category: l-type lectin]] | ||
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Revision as of 14:10, 30 October 2007
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STRUCTURE OF A THROMBOSPONDIN C-TERMINAL FRAGMENT REVEALS A NOVEL CALCIUM CORE IN THE TYPE 3 REPEATS
OverviewOverview
Thrombospondins (TSPs) are extracellular regulators of cell-matrix, interactions and cell phenotype. The most highly conserved region of all, TSPs are the calcium-binding type 3 (T3) repeats and the C-terminal, globular domain (CTD). The crystal structure of a cell-binding TSP-1, fragment, spanning three T3 repeats and the CTD, reveals a compact, assembly. The T3 repeats lack secondary structure and are organised around, a core of calcium ions; two DxDxDGxxDxxD motifs per repeat each, encapsulate two calcium ions in a novel arrangement. The CTD forms a, lectin-like beta-sandwich and contains four strictly conserved, calcium-binding sites. Disruption of the hairpin structure of T3 repeats 6, and 7 decreases protein secretion and stability. The availability for cell, attachment of an RGD ... [(full description)]
About this StructureAbout this Structure
1UX6 is a [Single protein] structure of sequence from [Homo sapiens] with CA as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats., Kvansakul M, Adams JC, Hohenester E, EMBO J. 2004 Mar 24;23(6):1223-33. Epub 2004 Mar 11. PMID:15014436
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