1ux9: Difference between revisions
New page: left|200px<br /> <applet load="1ux9" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ux9, resolution 2.4Å" /> '''MAPPING PROTEIN MATR... |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
1UX9 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with XE, HEM and FC6 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UX9 OCA]]. | 1UX9 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with XE, HEM and FC6 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UX9 OCA]]. | ||
==Reference== | ==Reference== | ||
| Line 29: | Line 29: | ||
[[Category: transport]] | [[Category: transport]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:14:48 2007'' | ||
Revision as of 14:10, 30 October 2007
|
MAPPING PROTEIN MATRIX CAVITIES IN HUMAN CYTOGLOBIN THROUGH XE ATOM BINDING: A CRYSTALLOGRAPHIC INVESTIGATION
OverviewOverview
Cytoglobin is the fourth recognized globin type, almost ubiquitously, distributed in human tissues; its function is still poorly understood., Cytoglobin displays a core region of about 150 residues, structurally, related to hemoglobin and myoglobin, and two extra segments, about 20, residues each, at the N- and C-termini. The core region hosts a large, apolar cavity, held to provide a ligand diffusion pathway to/from the, heme, and/or ligand temporary docking sites. Here we report the crystal, structure (2.4A resolution, R-factor 19.1%) of a human cytoglobin mutant, bearing the CysB2(38) --> Ser and CysE9(83) --> Ser substitutions (CYGB*), treated under pressurized xenon. Three Xe atoms bind to the heme distal, site region of CYGB* mapping the protein matrix apolar cavity. Despite ... [(full description)]
About this StructureAbout this Structure
1UX9 is a [Single protein] structure of sequence from [Homo sapiens] with XE, HEM and FC6 as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Mapping protein matrix cavities in human cytoglobin through Xe atom binding., de Sanctis D, Dewilde S, Pesce A, Moens L, Ascenzi P, Hankeln T, Burmester T, Bolognesi M, Biochem Biophys Res Commun. 2004 Apr 16;316(4):1217-21. PMID:15044115
Page seeded by OCA on Tue Oct 30 13:14:48 2007