User:Anthony Davis/Sandbox1 IgE: Difference between revisions

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=Causes=

There are two main factors that contribute to the development of IgE mediated allergies and these are genetic and environmental. There are several genes that may make people susceptible to allergic reactions one such gene is located on chromosome 11q12-13 and is associated with asthma. There are four main environmental factors which are allergen levels, environmental pollution, dietary changes and changes and exposure to infectious diseases in early childhood.

~~=Research=~~

Current research involves allergy drugs that will disrupt or interfere with the interaction between IgE and its Fc receptor. The drug Omalizumab (trade name Xolair) is one such drug that is in use today to help people with allergic asthma. It works by binding to IgE thus interfering with its ability to bind to its receptor and induce an immune response. A recent study has shown an antibody (XmAb7195) to have five times more affinity to IgE than Omalizumab. Research pertaining to IgE and its FcϵRI receptor will continue to be important in regards to the treatment of allergic reactions and asthma.

=Structure=

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</scene>

The four tryptophans form a flat, hydrophobic ridge that neighbors the D2 FG loop. This unusual arrangement of four exposed tryptophans probably forms a contact surface for a complementary interaction with the IgE.

=Research=

Current research involves allergy drugs that will disrupt or interfere with the interaction between IgE and its Fc receptor. The drug Omalizumab (trade name Xolair) is one such drug that is in use today to help people with allergic asthma. It works by binding to IgE thus interfering with its ability to bind to its receptor and induce an immune response. A recent study has shown an antibody (XmAb7195) to have five times more affinity to IgE than Omalizumab. Research pertaining to IgE and its FcϵRI receptor will continue to be important in regards to the treatment of allergic reactions and asthma.

=References=

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 =Causes=
 There are two main factors that contribute to the development of IgE mediated allergies and these are genetic and environmental. There are several genes that may make people susceptible to allergic reactions one such gene is located on chromosome 11q12-13 and is associated with asthma. There are four main environmental factors which are allergen levels, environmental pollution, dietary changes and changes and exposure to infectious diseases in early childhood.
-=Research=
-Current research involves allergy drugs that will disrupt or interfere with the interaction between IgE and its Fc receptor. The drug Omalizumab (trade name Xolair) is one such drug that is in use today to help people with allergic asthma. It works by binding to IgE thus interfering with its ability to bind to its receptor and induce an immune response. A recent study has shown an antibody (XmAb7195) to have five times more affinity to IgE than Omalizumab. Research pertaining to IgE and its FcϵRI receptor will continue to be important in regards to the treatment of allergic reactions and asthma.
 =Structure=
@@ Line 29: / Line 26: @@
 </scene>
 The four tryptophans form a flat, hydrophobic ridge that neighbors the D2 FG loop. This unusual arrangement of four exposed tryptophans probably forms a contact surface for a complementary interaction with the IgE.
+=Research=
+Current research involves allergy drugs that will disrupt or interfere with the interaction between IgE and its Fc receptor. The drug Omalizumab (trade name Xolair) is one such drug that is in use today to help people with allergic asthma. It works by binding to IgE thus interfering with its ability to bind to its receptor and induce an immune response. A recent study has shown an antibody (XmAb7195) to have five times more affinity to IgE than Omalizumab. Research pertaining to IgE and its FcϵRI receptor will continue to be important in regards to the treatment of allergic reactions and asthma.
 =References=