Vibrio cholerae colonization factor TcpF: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Yang Yang, Alexander Berchansky, Michal Harel

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 {{STRUCTURE_3oc5|  PDB=3oc5  | SIZE=300| SCENE=Vibrio_cholerae_colonization_factor_TcpF/Consurf/1 |right|CAPTION=Consurf image [[3oc5]] }}
-TcpF is the only protein secreted by the TCP apparatus and it represents the first nonpilus protein identified that is specifically secreted outside the bacterial cell by a type IV pilus biogenesis apparatus. Studies shows that TcpF, identified in classical isolates of V. cholerae O1 is an essential factor for colonization in the infant mouse cholera model. Bacteria lacking tcpF are deficient in colonization, and anti-TcpF antibodies are protective in the infant mouse cholera model. TcpF is expressed in vivo during human infection and generates a substantial immune response in patients infected with V. cholera.
+The function of many of Tcp genes and their associated proteins are largely unknown. TcpF is the only protein secreted by the TCP apparatus and it represents the first nonpilus protein identified that is specifically secreted outside the bacterial cell by a type IV pilus biogenesis apparatus. Studies hypothesize that TcpF, identified in classical isolates of V. cholerae O1 is an essential factor for colonization in the infant mouse cholera model. Bacteria lacking tcpF are deficient in colonization, and anti-TcpF antibodies are protective in the infant mouse cholera model. TcpF is expressed in vivo during human infection and generates a substantial immune response in patients infected with V. cholera.
 == Evolution ==