Vibrio cholerae colonization factor TcpF: Difference between revisions
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== Evolution == | == Evolution == | ||
{{STRUCTURE_3oc5| PDB=3oc5 | SIZE=300| SCENE=Vibrio_cholerae_colonization_factor_TcpF/Consurf/1 |right|CAPTION=Consurf image [[3oc5]] }} | |||
[[Image:Msatcpf.png|left|300px|thumb| Multiple sequence Alignment [[1xtc]]]] | [[Image:Msatcpf.png|left|300px|thumb| Multiple sequence Alignment [[1xtc]]]] | ||
[[Image:Distancematrixtcpf.png|left|300px|thumb| Distance Matrix [[1xtc]]]] | [[Image:Distancematrixtcpf.png|left|300px|thumb| Distance Matrix [[1xtc]]]] | ||
The environmental TcpF proteins are important for secretion because they retained a high degree of identity in the region. Each of the environmental TcpF proteins examined was secreted from the pathogenic strains. Now, TcpF genes from six pathogenic strains of V. cholerae have been sequenced, and all of these strains have nearly identical TcpF amino acid sequences.However, studies examined that environmental TcpF proteins cannot mediate colonization in the infant mouse cholera model. By comparing the environmental strain, SCE4 and the pathogenic TcpF, O395 (See Multiple sequence alignment result ), it revealed that the regions, divergent from one another are located at the middle of the C terminal domain. Therefore, lack of colonization mediated by environmental TcpF proteins may suggest that the divergent regions between the pathogenic and environmental proteins are essential for TcpF function. | The environmental TcpF proteins are important for secretion because they retained a high degree of identity in the region. Each of the environmental TcpF proteins examined was secreted from the pathogenic strains. Now, TcpF genes from six pathogenic strains of V. cholerae have been sequenced, and all of these strains have nearly identical TcpF amino acid sequences.However, studies examined that environmental TcpF proteins cannot mediate colonization in the infant mouse cholera model. By comparing the environmental strain, SCE4 and the pathogenic TcpF, O395 (See Multiple sequence alignment result ), it revealed that the regions, divergent from one another are located at the middle of the C terminal domain. Therefore, lack of colonization mediated by environmental TcpF proteins may suggest that the divergent regions between the pathogenic and environmental proteins are essential for TcpF function. | ||