NAC transcription factor: Difference between revisions

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OCA, Hao Chen, David Canner, Michal Harel, Jaime Prilusky, Alexander Berchansky

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 Vascular-related NAC-domain transcription facor (VND) is one group of the largest plant-specific transcription factor NAC family. The VND1-VND7 were orginally isolated as genes for which expression levels are elevated during transdifferentiation into trachery elements, in a induction system using Arabidopsis suspension cells <ref>http://genesdev.cshlp.org/content/19/16/1855.full.pdf</ref>.In the past several years, VNDs have been intensively investigated in different species and shown to be important switches of the biosynthesis of secondary cell walls that provide textiles, timber, and potentially second-generation bio-fuels for human use<ref>http://mplant.oxfordjournals.org/content/early/2011/12/01/mp.ssr098.full.pdf+html
 </ref><ref>http://www.springerlink.com/content/qq1584g690243n16/fulltext.pdf
-</ref>. VNDs are grouped in NAC-c subfamily <ref></ref>. Typically, the proteins in this subfamily share a well conserved N-terminal NAC domain (-150 amino acid;aa) and a diversified C-terminal transcription regulatory region  <ref>www.ncbi.nlm.nih.gov/pubmed/15708345</ref> <ref>http://www.nature.com/embor/journal/v5/n3/pdf/7400093.pdf</ref>. The N-terminal NAC domain is usually responsible for DNA binding and dimerization, and the C-terminal region function in transcription activation , repression and protein binding. X-ray crystallography have exhibited the structure of conserved NAC domains when they form dimer and bind with DNA. However, due to the diversified sequence of C-terminal region, no structure analyses haven't been conducted in the region.
+</ref>. VNDs are grouped in NAC-c subfamily. Typically, the proteins in this subfamily share a well conserved N-terminal NAC domain (-150 amino acid;aa) and a diversified C-terminal transcription regulatory region  <ref>www.ncbi.nlm.nih.gov/pubmed/15708345</ref> <ref>http://www.nature.com/embor/journal/v5/n3/pdf/7400093.pdf</ref>. The N-terminal NAC domain is usually responsible for DNA binding and dimerization, and the C-terminal region function in transcription activation , repression and protein binding. X-ray crystallography have exhibited the structure of conserved NAC domains when they form dimer and bind with DNA. However, due to the diversified sequence of C-terminal region, no structure analyses haven't been conducted in the region.