Sandbox Reserved 467: Difference between revisions
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CDKs are activated through physical association with cyclin, a family of proteins, in which their abundance and proteolysis pattern within the cell vary according to the stage of cell cycle. Major transitions in the cell cycle are caused by activation of CDKs 1-4, which causes phosphorylation and dephosphorylation of key residues. Cells enter mitosis as protein-bound phosphates increase (Hames et al., 1998). In mammalian cells, it had been suggested that CDK-3, along with CDK-2, are required for G1/S stage (Hutchison p.111). Compared to CDK-1, 2, and 4, the role of CDK-3 is still unclear, as no cyclin partner had been found for it. However, it had been shown that it delays cells in the G1 phase (Hutchison, p.149). | CDKs are activated through physical association with cyclin, a family of proteins, in which their abundance and proteolysis pattern within the cell vary according to the stage of cell cycle. Major transitions in the cell cycle are caused by activation of CDKs 1-4, which causes phosphorylation and dephosphorylation of key residues. Cells enter mitosis as protein-bound phosphates increase (Hames et al., 1998). In mammalian cells, it had been suggested that CDK-3, along with CDK-2, are required for G1/S stage (Hutchison p.111). Compared to CDK-1, 2, and 4, the role of CDK-3 is still unclear, as no cyclin partner had been found for it. However, it had been shown that it delays cells in the G1 phase (Hutchison, p.149). | ||
[[Image:cell_cycle_3.jpg]] | [[Image:cell_cycle_3.jpg]] <ref>http://scientopia.org/blogs/scicurious/2010/05/31/cell-cycle-p21-depression-and-neurogenesis-and-in-the-hippocampus/</ref> | ||
Cdk’s are found in Eukaryotes, including human and yeast cells. Each organism has a different number of Cdks. In yeast, there is less, and more in humans. It is easier to study which Cdk is responsible for which part of the cell cycle in yeast than in humans, because of the level of complexity of Cdk and other cell activities in Homo Sapiens <ref name="overall cdk">. However, the function of Cdk is similar in all organisms in that it is part of the cell cycle regulation. For this reason, Cdk is often studied as targets for cancer treatment. | Cdk’s are found in Eukaryotes, including human and yeast cells. Each organism has a different number of Cdks. In yeast, there is less, and more in humans. It is easier to study which Cdk is responsible for which part of the cell cycle in yeast than in humans, because of the level of complexity of Cdk and other cell activities in Homo Sapiens <ref name="overall cdk">. However, the function of Cdk is similar in all organisms in that it is part of the cell cycle regulation. For this reason, Cdk is often studied as targets for cancer treatment. | ||