1o7z: Difference between revisions
New page: left|200px<br /> <applet load="1o7z" size="450" color="white" frame="true" align="right" spinBox="true" caption="1o7z, resolution 1.92Å" /> '''CRYSTAL STRUCTURE O... |
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'''CRYSTAL STRUCTURE OF IP-10 T-FORM'''<br /> | '''CRYSTAL STRUCTURE OF IP-10 T-FORM'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1O7Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | 1O7Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O7Z OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: interferon induction]] | [[Category: interferon induction]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:33:19 2008'' | ||
Revision as of 17:33, 15 February 2008
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CRYSTAL STRUCTURE OF IP-10 T-FORM
OverviewOverview
We have determined the structure of wild-type IP-10 from three crystal, forms. The crystals provide eight separate models of the IP-10 chain, all, differing substantially from a monomeric IP-10 variant examined previously, by NMR spectroscopy. In each crystal form, IP-10 chains form conventional, beta sheet dimers, which, in turn, form a distinct tetrameric assembly., The M form tetramer is reminiscent of platelet factor 4, whereas the T and, H forms feature a novel twelve-stranded beta sheet. Analytical, ultracentrifugation indicates that, in free solution, IP-10 exists in a, monomer-dimer equilibrium with a dissociation constant of 9 microM. We, propose that the tetrameric structures may represent species promoted by, the binding of glycosaminoglycans. The binding sites for several, IP-10-neutralizing mAbs have also been mapped.
About this StructureAbout this Structure
1O7Z is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine., Swaminathan GJ, Holloway DE, Colvin RA, Campanella GK, Papageorgiou AC, Luster AD, Acharya KR, Structure. 2003 May;11(5):521-32. PMID:12737818
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